Document Detail


Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid).
MedLine Citation:
PMID:  17942150     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previously we demonstrated the ability of ethyl glycinato substituted polyphosphazenes to neutralize the acidic degradation products and control the degradation rate of poly(lactic acid-glycolic acid) (PLAGA) by blending. In this study, blends of high strength poly[(50% ethyl alanato) (50% p-phenyl phenoxy) phosphazene] (PNEA(50)PhPh(50)) and 85:15 PLAGA were prepared using a mutual solvent approach. Three different solvents, methylene chloride (MC), chloroform (CF) and tetrahydrofuran (THF) were studied to investigate solvent effects on blend miscibility. Three different blends were then fabricated at various weight ratios namely 25:75 (BLEND25), 50:50 (BLEND50), and 75:25 (BLEND75) using THF as the mutual solvent. The miscibility of the blends was evaluated by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Among these, BLEND25 was miscible while BLEND50 and BLEND75 were partially miscible. Furthermore, BLEND25 formed apatite layers on its surface as evidenced in a biomimetic study performed. These novel blends showed cell adhesion and proliferation comparable to PLAGA. However, the PNEA(50)PhPh(50) component in the blends was able to increase the phenotypic expression and mineralized matrix synthesis of the primary rat osteoblasts (PRO) in vitro. Blends of high strength PNEA(50)PhPh(50) and 85:15 PLAGA are promising biomaterials for a variety of musculoskeletal applications.
Authors:
Meng Deng; Lakshmi S Nair; Syam P Nukavarapu; Sangamesh G Kumbar; Tao Jiang; Nicholas R Krogman; Anurima Singh; Harry R Allcock; Cato T Laurencin
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-10-17
Journal Detail:
Title:  Biomaterials     Volume:  29     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-11-13     Completed Date:  2008-03-19     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  337-49     Citation Subset:  IM    
Affiliation:
Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, USA.
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MeSH Terms
Descriptor/Qualifier:
Alkaline Phosphatase / metabolism
Animals
Biocompatible Materials / chemistry*,  metabolism*
Biomimetic Materials / chemistry,  metabolism
Calorimetry, Differential Scanning
Cell Proliferation
Cell Shape
Cells, Cultured
Lactic Acid / chemistry*,  metabolism*
Microscopy, Electron, Scanning
Molecular Structure
Organophosphorus Compounds / chemistry*,  metabolism*
Osteoclasts / cytology,  metabolism*
Polymers / chemistry*,  metabolism*
Rats
Solvents
Spectroscopy, Fourier Transform Infrared
Surface Properties
Grant Support
ID/Acronym/Agency:
R01 EB004051/EB/NIBIB NIH HHS; R01 EB004051-02/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Organophosphorus Compounds; 0/Polymers; 0/Solvents; 0/poly((ethyl alanato) (p-phenyl phenoxy) phosphazene); 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid; EC 3.1.3.1/Alkaline Phosphatase
Comments/Corrections

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