Document Detail

Misbehaving macrophages in the pathogenesis of psoriasis.
MedLine Citation:
PMID:  16886055     Owner:  NLM     Status:  MEDLINE    
Psoriasis is a chronic inflammatory skin disease unique to humans. In this issue of the JCI, 2 studies of very different mouse models of psoriasis both report that macrophages play a key role in inducing psoriasis-like skin disease. Psoriasis is clearly a polygenic, inherited disease of uncontrolled cutaneous inflammation. The debate that currently rages in the field is whether psoriasis is a disease of autoreactive T cells or whether it reflects an intrinsic defect within the skin--or both. However, these questions have proven difficult to dissect using molecular genetic tools. In the current studies, the authors have used 2 different animal models to address the role of macrophages in disease pathogenesis: Wang et al. use a mouse model in which inflammation is T cell dependent, whereas the model used by Stratis et al. is T cell independent (see the related articles beginning on pages 2105 and 2094, respectively). Strikingly, both groups report an important contribution by macrophages, implying that macrophages can contribute to both epithelial-based and T cell-mediated pathways of inflammation.
Rachael A Clark; Thomas S Kupper
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  116     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-03     Completed Date:  2006-09-14     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2084-7     Citation Subset:  AIM; IM    
Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
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MeSH Terms
Disease Models, Animal
Inflammation / immunology,  physiopathology
Macrophage Activation
Macrophages / immunology,  physiology*
Psoriasis / etiology,  immunology,  physiopathology*
Grant Support
1K08AI060890-01A1/AI/NIAID NIH HHS; 1U19 AI57330-01/AI/NIAID NIH HHS; HHSN266200400030C//PHS HHS; P30 AR-42689-11/AR/NIAMS NIH HHS; P50 CA-93683-04/CA/NCI NIH HHS; R01 AI-41707-09/AI/NIAID NIH HHS; R37 AI-25082-17/AI/NIAID NIH HHS
Comment On:
J Clin Invest. 2006 Aug;116(8):2094-104   [PMID:  16886058 ]
J Clin Invest. 2006 Aug;116(8):2105-14   [PMID:  16886059 ]
Comment In:
J Clin Invest. 2006 Dec;116(12):3088; author reply 3088-9   [PMID:  17143321 ]

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