Document Detail


Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila.
MedLine Citation:
PMID:  16280349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Incorrectly specified or mis-specified cells often undergo cell death or are transformed to adopt a different cell fate during development. The underlying cause for this distinction is largely unknown. In many developmental mutants in Drosophila, large numbers of mis-specified cells die synchronously, providing a convenient model for analysis of this phenomenon. The maternal mutant bicoid is particularly useful model with which to address this issue because its mutant phenotype is a combination of both transformation of tissue (acron to telson) and cell death in the presumptive head and thorax regions. We show that a subset of these mis-specified cells die through an active gene-directed process involving transcriptional upregulation of the cell death inducer hid. Upregulation of hid also occurs in oskar mutants and other segmentation mutants. In hid bicoid double mutants, mis-specified cells in the presumptive head and thorax survive and continue to develop, but they are transformed to adopt a different cell fate. We provide evidence that the terminal torso signaling pathway protects the mis-specified telson tissue in bicoid mutants from hid-induced cell death, whereas mis-specified cells in the head and thorax die, presumably because equivalent survival signals are lacking. These data support a model whereby mis-specification can be tolerated if a survival pathway is provided, resulting in cellular transformation.
Authors:
Christian Werz; Tom V Lee; Peter L Lee; Melinda Lackey; Clare Bolduc; David S Stein; Andreas Bergmann
Related Documents :
19799519 - Asymmetric distribution of epidermal growth factor receptor directs the fate of normal ...
20651349 - Inhibition of wnt signaling pathway decreases chemotherapy-resistant side-population co...
12813919 - Decoding the lim development code.
20178599 - Spatial discontinuity of optomotor-blind expression in the drosophila wing imaginal dis...
16434879 - Escrting cell proliferation off the beaten path: lessons from the drosophila eye.
18948759 - The control of egf signaling and cell fate in the drosophila abdomen.
3080409 - Streptococcal tetracycline resistance mediated at the level of protein synthesis.
8391329 - Heterogeneity in the storage of gonadotropins in the ovine fetus and evidence for lutei...
22065859 - Follicular assembly: mechanisms of action.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-09
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  132     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-29     Completed Date:  2007-08-17     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  5343-52     Citation Subset:  IM    
Affiliation:
The University of Texas M.D. Anderson Cancer Center, Department of Biochemistry and Molecular Biology, 1515 Holcombe Boulevard, Unit 1000, Houston, TX 77030, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning
Caspases / metabolism
Cell Death / physiology
Cell Differentiation / physiology
Cell Survival
Drosophila / embryology,  genetics,  physiology*
Drosophila Proteins / biosynthesis,  genetics,  physiology*
Embryo, Nonmammalian / cytology,  physiology
Enzyme Activation
Gene Expression Regulation, Developmental
Homeodomain Proteins / genetics,  physiology*
Mutation
Neuropeptides / biosynthesis,  genetics,  physiology*
Receptor Protein-Tyrosine Kinases / genetics,  physiology*
Signal Transduction
Trans-Activators / genetics,  physiology*
Grant Support
ID/Acronym/Agency:
R01 GM068016-02/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Homeodomain Proteins; 0/Neuropeptides; 0/Trans-Activators; 0/bicoid protein, Drosophila; 0/oskar protein, Drosophila; 0/wrinkled protein, Drosophila; EC 2.7.1.-/torso protein, Drosophila; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 3.4.22.-/Caspases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pelota controls self-renewal of germline stem cells by repressing a Bam-independent differentiation ...
Next Document:  Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS im...