Document Detail

Mirtazapine use in resistant hyperemesis gravidarum: report of three cases and review of the literature.
MedLine Citation:
PMID:  16007504     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hyperemesis gravidarum is a serious health problem for the fetus and the mother. Effective treatment regimens are obscure in patients with severe symptoms. Our aim was to use mirtazapine in hyperemesis gravidarum patients who failed to respond to conventional anti-emetic drugs. CASES: Three pregnant women who had severe hyperemesis gravidarum. All patients had dehydration, ketonuria, hypokalemia, and weight loss. All failed to respond to conventional anti-emesis treatment regimens, such as metoclopramide and promethazine. Al patients had mirtazapine 30 mg/day within the intravenous fluid support approximately for 1 week. All responded to mirtazapine within 24 h and were able to resume diet within a few days after the initiation of treatment. None of these pregnant women had any disturbing symptoms of emesis throughout the pregnancy and had healthy newborns. CONCLUSION: Mirtazapine seems to be an effective treatment modality in patients with severe hyperemesis gravidarum who do not respond to conventional anti-emesis treatment regimens. Larger-scaled studies should be performed to show the effectiveness of mirtazapine in pregnant women with severe hyperemesis gravidarum who may request pregnancy termination.
Serkan Guclu; Mert Gol; Erbil Dogan; Ugur Saygili
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-10-13
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  272     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  298-300     Citation Subset:  IM    
Faculty of Medicine, Department of Obstetrics & Gynecology, Dokuz Eylul University, Izmir, Turkey.
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MeSH Terms
Antiemetics / therapeutic use*
Hyperemesis Gravidarum / drug therapy*
Infant, Newborn
Mianserin / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Antiemetics; 24219-97-4/Mianserin; 61337-67-5/mirtazapine

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