| Mirtazapine relieves post-electroconvulsive therapy headaches and nausea: a case series and review of the literature. | |
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MedLine Citation:
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PMID: 21602639 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Headaches and nausea are the 2 most common adverse effects of electroconvulsive therapy (ECT). These adverse effects have been frequently reported in the postictal period and make it difficult for the patient to continue with the following ECTs. Mirtazapine is an antidepressant with a mechanism that involves activating serotonin (5-HT1) receptors. This mechanism has been hypothesized to be the underlying therapeutic effects for depression and anxiety. In addition, mirtazapine possesses antagonistic effects on the postsynaptic serotonin 5-HT2 and 5-HT3 receptors. The pharmacological actions are hypothesized to be related to its treatment effects of headaches and nausea. Here, we report a case series of patients developing post-ECT headaches and nausea, and the concomitant administration of mirtazapine successfully relieved the ECT-associated adverse effects. This case series suggest that mirtazapine may be an optional treatment for ECT-induced headaches and nausea. |
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Authors:
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Tien-Chun Li; I-Shin Shiah; Chia-Jui Sun; Ruu-Fen Tzang; Kuo-Chuan Huang; Wen-Kuei Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of ECT Volume: 27 ISSN: 1533-4112 ISO Abbreviation: J ECT Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808943 Medline TA: J ECT Country: United States |
Other Details:
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Languages: eng Pagination: 165-7 Citation Subset: IM |
Affiliation:
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From the *Department of Psychiatry, Armed Forces Beitou Hospital; †Department of Psychiatry, Tri-Service General Hospital, Taipei; ‡Department of Psychiatry, Chutung Veterans Hospital, Hsinchu County; and §Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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