| Mirtazapine induces REM sleep behavior disorder (RBD) in parkinsonism. | |
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MedLine Citation:
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PMID: 12525729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Shortly after initiation of mirtazapine (a noradrenergic and serotonergic antidepressant) treatment in four patients with parkinsonism, the authors observed the appearance of REM sleep behavior disorder (RBD). In the two patients with severe motor symptoms, RBD was accompanied by hallucinations and confusion. These disturbances resolved with drug discontinuation, and remained resolved by 12- to 24-month follow-up, suggesting that RBD can be triggered by a drug lacking anticholinergic activity. |
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Authors:
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M Onofrj; A L Luciano; A Thomas; D Iacono; G D'Andreamatteo |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurology Volume: 60 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-14 Completed Date: 2003-01-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 113-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Oncology and Neuroscience, University G. D'Annunzio, Pescara, Italy. onofrj@unich.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antidepressive Agents, Tricyclic / adverse effects* Depression / complications, drug therapy Electroencephalography Humans Levodopa / therapeutic use Male Mianserin / adverse effects*, analogs & derivatives* Neuropsychological Tests Parkinsonian Disorders / complications, drug therapy* Polysomnography REM Sleep Behavior Disorder / chemically induced*, complications |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic; 0/Levodopa; 24219-97-4/Mianserin; 61337-67-5/mirtazapine |
| Comments/Corrections | |
Comment In:
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Neurology. 2003 Oct 28;61(8):1161; author reply 1161
[PMID:
14581700
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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