Document Detail

Mirtazapine augmentation enhances cognitive and reduces negative symptoms in schizophrenia patients treated with risperidone: A randomized controlled trial.
MedLine Citation:
PMID:  21095214     Owner:  NLM     Status:  In-Data-Review    
This preliminary study aimed to determine if adding mirtazapine to risperidone might improve negative and cognitive symptoms in schizophrenia. In an 8-week, double-blind clinical trial, we randomly assigned 21 stabilized outpatients with schizophrenia undergoing risperidone treatment to adjunctive treatment with either mirtazapine or a placebo. The mirtazapine group exhibited a statistically significant improvement in cognitive function, including vocabulary and immediate memory, and negative symptoms (as measured by negative symptom scales) and showed an adverse effect of 5.83kg mean weight gain. This study suggests augmenting risperidone with mirtazapine can effectively improve both negative and some cognitive symptoms of schizophrenia. RESEARCH HIGHLIGHTS: ► Mirtazapine enhances some cognitive symptoms of schizophrenia. ► Mirtazapine reduces negative symptoms of schizophrenia.
Sung Joon Cho; Keunyoung Yook; Borah Kim; Tai Kiu Choi; Kang Soo Lee; Yong Woo Kim; Ji Eun Lee; Shinyoung Suh; Ki Hwan Yook; Sang-Hyuk Lee
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Publication Detail:
Type:  Journal Article     Date:  2010-11-21
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  35     ISSN:  1878-4216     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  208-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
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