| Mirizzi syndrome and gallbladder cancer. | |
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MedLine Citation:
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PMID: 16858544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/PURPOSE: Mirizzi syndrome is a rare complication of gallstone disease (GSD). The association of Mirizzi syndrome and gallbladder carcinoma (GBC) is not well understood. We report our experience of gallbladder carcinoma in patients with Mirizzi syndrome. METHODS: We performed a retrospective analysis of the records of patients with Mirizzi syndrome who underwent cholecystectomy at a tertiary care hospital with special emphasis on patients who were found to harbor GBC. Patients with Mirizzi syndrome with associated GBC were compared with those who had Mirizzi syndrome alone and those with uncomplicated GSD. RESULTS: Out of 4,800 cholecystectomies, Mirizzi syndrome was found in 133 (2.8%). Seven (5.3%) patients with Mirizzi syndrome had associated GBC, as compared to only 1% in patients with GSD. GBC was detected on final histology after cholecystectomy in 5 patients, and was detected preoperatively and intraoperatively in 1 patient each. Patients with Mirizzi syndrome with associated GBC were older (60 vs 50 years; P <or= 0.0001) and had a longer duration of symptoms (59 vs 24 months; P = 0.002) as compared to those with Mirizzi syndrome alone. However, presenting clinical features were not different in these two groups. CONCLUSIONS: There was a higher incidence of GBC in patients with Mirizzi syndrome than in patients with uncomplicated GSD. There were no clinical features to differentiate these patients with GBC from those with Mirizzi syndrome alone, except that they were a decade older and had longer duration of symptoms. In the majority, the diagnosis of GBC was made on final histology, after cholecystectomy; hence, this group of patients with GBC are to be treated like any other patients with incidental GBC. |
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Authors:
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Theegala L V D Prasad; Ashok Kumar; Sadiq S Sikora; Rajan Saxena; Vinay K Kapoor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hepato-biliary-pancreatic surgery Volume: 13 ISSN: 0944-1166 ISO Abbreviation: J Hepatobiliary Pancreat Surg Publication Date: 2006 |
Date Detail:
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Created Date: 2006-07-21 Completed Date: 2007-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431940 Medline TA: J Hepatobiliary Pancreat Surg Country: Japan |
Other Details:
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Languages: eng Pagination: 323-6 Citation Subset: IM |
Affiliation:
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Department of Surgical Gastroenterology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, UP, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biliary Fistula / epidemiology* Common Bile Duct Diseases / epidemiology*, pathology Female Gallbladder Neoplasms / epidemiology*, pathology Humans India / epidemiology Male Middle Aged Retrospective Studies Syndrome |
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