| Minute chromatin structures in cells of amniotic fluid-an interpretative dilemma. | |
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MedLine Citation:
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PMID: 7845896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Single copies of tiny chromosome fragments, appearing either as single or as double minutes, were observed in a high frequency in amniotic fluid cultures of five mothers who underwent prenatal testing because of advanced age. In four cases, the minutes had arisen de novo. The minutes were later confirmed in fetal skin following termination of pregnancy in one case; in another, in cord blood following the birth of a normal boy; and in the third, in peripheral blood of a normal 3-year-old girl. In the fourth case, the minutes were not confirmed in cord blood following the birth of a normal boy. A follow-up chromosome study of the baby boy in the fifth case was not possible but the minutes were maternally transmitted. |
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Authors:
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H Wang; J L Bellinger; K Brierley; L E Dawson; C L Goldsmith; A G Hunter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 14 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-03-08 Completed Date: 1995-03-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 868-72 Citation Subset: IM |
Affiliation:
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Division of Genetics, Children's Hospital of Eastern Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniocentesis* Amniotic Fluid / chemistry*, cytology* Chromatin / ultrastructure* Chromosomes / ultrastructure Female Fetal Blood / cytology Humans Karyotyping Male Pregnancy Pregnancy Trimester, Second Skin / cytology |
| Chemical | |
Reg. No./Substance:
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0/Chromatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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