Document Detail

Minoxidil versus nitroglycerine: a prospective, double-blind, controlled trial in transcutaneous therapy for organic impotence.
MedLine Citation:
PMID:  7795721     Owner:  NLM     Status:  MEDLINE    
Minoxidil (1 ml, 2% solution) has been tested against nitroglycerine (2.5 g, 10% ointment) and placebo in a prospective, double-blind controlled trial in transcutaneous therapy for organic impotence. A total of 116 patients participated in the study. Impotence aetiology breakdown was as follows: arterial, 61 cases; neurogenic, 34; arterial plus neurogenic, 12; venous leakage, 9. The application sites for treatment were: glans penis (minoxidil and placebo), penile shaft (nitroglycerine). All patients underwent through sexological counselling sessions (at outset and prior to subsequent changes in drug used). The results were considered positive if all symptoms of impotence (ie 'slow' erection, loss of erection, insufficient erection) were resolved; if even one symptom remained the results were considered negative. Side-effects were also considered. Minoxidil proved significantly more active than nitroglycerine which was, in turn, more effective than placebo. Minoxidil proved significantly more active in neurogenic impotent patients. Fewer side-effects were found with minoxidil than with nitroglycerine. These data lead one to consider minoxidil useful in the treatment of selected cases of organic impotence, as long as psychological conflict regarding sex and drug use are carefully removed.
G Cavallini
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of impotence research     Volume:  6     ISSN:  0955-9930     ISO Abbreviation:  Int. J. Impot. Res.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-07-28     Completed Date:  1995-07-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007383     Medline TA:  Int J Impot Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
Department of Urology, Hospital of Adria-ULSS, Veneto, Italy.
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MeSH Terms
Administration, Cutaneous
Double-Blind Method
Erectile Dysfunction / drug therapy*
Middle Aged
Minoxidil / administration & dosage,  adverse effects,  therapeutic use*
Nitroglycerin / administration & dosage,  adverse effects,  therapeutic use*
Prospective Studies
Reg. No./Substance:
0/Placebos; 38304-91-5/Minoxidil; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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