Document Detail

Minoxidil, nadolol, and a diuretic. Once-a-day therapy for resistant hypertension.
MedLine Citation:
PMID:  3963979     Owner:  NLM     Status:  MEDLINE    
We tested a once-a-day antihypertensive regimen using minoxidil, nadolol, and a diuretic in 55 patients with resistant hypertension. Forty-seven patients had evidence of end-organ damage. Twelve had mild renal insufficiency (serum creatinine concentration, 2.5 +/- 0.3 mg/dL). In 34 patients, treatment with nadolol and a diuretic was started with minoxidil added one to four weeks later. In the remainder, minoxidil, nadolol, and a diuretic were begun simultaneously because of severe hypertension. Initial supine and standing blood pressure (BP) in the 55 patients were 186 +/- 4/111 +/- 2 and 180 +/- 4/108 +/- 2 mm Hg, respectively. After 7 +/- 1 weeks, BP was controlled in 46 patients (84%) with the supine and standing BP reduced to 140 +/- 3/80 +/- 1 and 134 +/- 3/80 +/- 1, respectively. In six patients, BP was controlled but intolerable side effects occurred, making the regimen therapeutically successful in 40 patients (73%). The BP remained controlled during a follow-up of 43 +/- 5 weeks. In 31 patients, BPs measured 24 hours after the last dose were not different from random measurements. Mean serum creatinine levels remained stable in the 12 patients with renal insufficiency.
S Spitalewitz; J G Porush; I W Reiser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  146     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-05-22     Completed Date:  1986-05-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  882-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Creatinine / blood
Diuretics / administration & dosage*,  therapeutic use
Drug Administration Schedule
Drug Therapy, Combination
Follow-Up Studies
Hypertension / drug therapy*,  physiopathology
Middle Aged
Minoxidil / administration & dosage*,  therapeutic use
Propanolamines / administration & dosage*,  therapeutic use
Reg. No./Substance:
0/Diuretics; 0/Propanolamines; 38304-91-5/Minoxidil; 42200-33-9/Nadolol; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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