| Minor segmental wall motion abnormalities detected in patients with Chagas' disease have adverse prognostic implications. | |
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MedLine Citation:
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PMID: 16612471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent data from our laboratory have shown that patients with the indeterminate form of Chagas' disease can have impairment of left ventricular contractility, as evaluated by the slope of the left ventricle end-systolic pressure-dimension relationship. We also showed that Chagas' disease patients with minimal baseline wall motion abnormalities detected by two-dimensional echocardiography have more intense contractility impairment when compared to patients with the indeterminate form of the disease without this abnormality. The prognostic implications of these findings have not been established. We evaluated 59 patients (37-76 years, mean = 55 years) with different clinical forms of Chagas' disease, who had normal left ventricular global systolic function at baseline (57.6 +/- 6.9%) and who had at least one additional echo during clinical follow-up (0.4-17.6; mean 4.6 years). Group 1 consisted of 14 patients with minor baseline left ventricle wall motion abnormalities and group 2 consisted of 45 patients without these abnormalities. During follow-up, global left ventricle systolic function deterioration was observed in 10 group 1 patients (71.4%) and in only 10 group 2 patients (22.2%; P < 0.005). Age and duration of follow-up were not independent determinants of left ventricular function deterioration in these patients. The present data indicate that mild segmental left ventricular wall motion abnormalities are associated with worsening of systolic function in Chagas' disease patients who have normal baseline global systolic performance. |
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Authors:
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A Pazin-Filho; M M D Romano; O C Almeida-Filho; M S Furuta; L F Viviani; A Schmidt; J A Marin-Neto; B C Maciel |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-04-03 |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 39 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-13 Completed Date: 2007-02-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: Brazil |
Other Details:
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Languages: eng Pagination: 483-7 Citation Subset: IM |
Affiliation:
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Divisão de Cardiologia, Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Chagas Cardiomyopathy / physiopathology, ultrasonography Chagas Disease / physiopathology* Chronic Disease Echocardiography Female Follow-Up Studies Humans Male Middle Aged Myocardial Contraction / physiology* Prognosis Severity of Illness Index Ventricular Dysfunction, Left / physiopathology*, ultrasonography |
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