Document Detail

Minor interference of low-dose pulses of GnRH with the positive effect of oestradiol on the pituitary gland.
MedLine Citation:
PMID:  3120450     Owner:  NLM     Status:  MEDLINE    
In the ovariectomized rat we investigated the effects of prolonged treatment with oestradiol and 'physiological' pulses of exogenous GnRH on the GnRH-responsiveness of the pituitary gland. Rats were for 20 h pre-treated with either GnRH (3-ng pulses of 3 min duration every 20 min) or saline and for 19 h with either oestradiolbenzoate (OB; 3 micrograms/sc injection) or oil. Then LH and FSH responses were evoked by continuous test infusions of GnRH at the rates of either 60, 100, 150 or 1000 ng/h, lasting 10 h. It appeared that, irrespective of pre-treatment with either GnRH or saline, OB caused an increase of the maximal LH and FSH responses (that is the responses to the maximal stimulus of 1000 ng GnRH/h), and an increase of the GnRH-sensitivity of the pituitary gland, as far as the FSH secretion is concerned. GnRH pulses caused, irrespective of pre-treatment with OB or oil, a decrease of the GnRH-sensitivity of the pituitary gland, as well as a decrease of the maximal FSH response and of the pituitary FSH content. It was concluded that low-dose pulses of exogenous GnRH desensitize the pituitary gland and deplete the pituitary FSH stores, but do not change the positive effect of oestradiol on the maximal gonadotropin response.
T R Koiter; G C van der Schaaf-Verdonk; N Pols-Valkhof; G A Schuiling
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  116     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-21     Completed Date:  1987-12-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  399-404     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Groningen University Hospital, The Netherlands.
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MeSH Terms
Dose-Response Relationship, Drug
Estradiol / administration & dosage*
Follicle Stimulating Hormone / secretion
Hypothalamus / drug effects
Luteinizing Hormone / secretion
Pituitary Gland / drug effects*
Pituitary Hormone-Releasing Hormones / administration & dosage*
Rats, Inbred Strains
Reg. No./Substance:
0/Pituitary Hormone-Releasing Hormones; 50-28-2/Estradiol; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

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