Document Detail


Minor increases in plasma troponin I predict decreased left ventricular ejection fraction after high-dose chemotherapy.
MedLine Citation:
PMID:  12560347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Increased cardiac troponin I (cTnI) in patients treated with high-dose chemotherapy (HDCT) for aggressive malignancy has been proposed as an early marker of late HDCT-induced cardiac dysfunction. We investigated whether cTnI measured by the Stratus CS (Dade Behring) would allow detection of minimal cTnI increases in patients treated with HDCT. METHODS: Plasma cTnI concentrations were determined in 179 consecutive patients before HDCT, at the end of the treatment, and after 12, 24, 36, and 72 h. Cardiac function was explored by echocardiography, and left ventricular ejection fraction (LVEF) was recorded during follow-up. The greatest variation in LVEF from the baseline value was used as a measure of cardiac damage. RESULTS: In 99 healthy volunteers, the 99th percentile was at 0.07 microg/L. On the basis of ROC curve analysis (area under the curve, 0.89), a cutoff of 0.08 microg/L was chosen (sensitivity, 82%; specificity, 77%). cTnI > or =0.08 microg/L occurred in 57 patients (32%) with echocardiographic monitoring revealing a mean decrease in LVEF of 18%. In comparison, the group of cTnI-negative patients had a mean decrease in LVEF of 2.5% (P <0.001). CONCLUSIONS: Plasma cTnI, as measured with the Stratus CS, can detect minor myocardial injury in patients treated with HDCT.
Authors:
Maria Teresa Sandri; Daniela Cardinale; Laura Zorzino; Rita Passerini; Paola Lentati; Alessandro Martinoni; Giovanni Martinelli; Carlo Maria Cipolla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  49     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  248-52     Citation Subset:  IM    
Affiliation:
Division of Pathology, Laboratory Medicine Unit, European Institute of Oncology, via Ripamonti 435, 20141 Milan, Italy. maris.sandri@ieo.it
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / administration & dosage,  adverse effects*
Dose-Response Relationship, Drug
Female
Humans
Male
Middle Aged
Prospective Studies
Stroke Volume / drug effects*
Troponin I / blood*
Ventricular Dysfunction, Left / chemically induced,  physiopathology,  ultrasonography*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Troponin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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