Document Detail


Minor changes in effective half-life during fractionated (177)Lu-Octreotate therapy.
MedLine Citation:
PMID:  21961497     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Aims. Fractionated (177)Lu-DOTA-octreotate therapy has been reported to be an effective treatment option for patients with generalized neuroendocrine tumors. In our clinic, full individual dosimetry is performed during the first therapy cycle, while dosimetry at later cycles is based on the 24 h uptake measurement assuming an unchanged effective half-life. Our aim was to evaluate this assumption and the variation in the 24 h uptake during therapy. Patients. Thirty patients, 13 women and 17 men, were included in the study. Methods. During the first therapy cycle the (177)Lu-concentration was measured with SPECT/CT over the abdomen at 24 h, 96 h and 168 h after infusion. The effective half-life was determined for the kidneys, liver and spleen. The procedure was repeated at cycle 4 or 5. Results. The median ratio between the effective half-lives of the latter and the first cycle was 0.97 and 1.01 for the right and left kidney, with a range of 0.89-1.01 (1st-3rd quartile) and 0.93-1.05, respectively. Discussion. The mean value of the ratios was slightly lower than one, indicating a tendency towards increased activity elimination during therapy. In individual patients, significant changes were found for all organs, often when a large tumor burden reduction occurred during treatment. Possible contributing factors appeared to be larger amounts of non-tumor bound tracer, improved organ function (kidneys), decrease of vessel obstruction (spleen), less scatter from large tumors and reduction of small metastases (liver and spleen). Conclusion. With most patients it is safe to estimate absorbed doses to kidneys, liver and spleen from 24 h activity concentration assuming an unchanged effective half-life during therapy. Patients with risk factors for kidney dysfunction need to be monitored in more detail. Simplified dosimetry based on the assumption of unchanged effective half-life can function as guidance to the number of therapy cycles an individual patient can tolerate.
Authors:
Ulrike Garske; Mattias Sandström; Silvia Johansson; Anders Sundin; Dan Granberg; Barbro Eriksson; Hans Lundqvist
Related Documents :
18607167 - Relationship between total and differential leukocyte counts and isolated coronary arte...
20956487 - Increased expression and plasma levels of myeloperoxidase are closely related to the pr...
15570357 - A comparison of clinical outcomes between canadian and american patients after nonurgen...
4016947 - Electrocardiographic st-t wave patterns, extent of coronary artery disease, and left ve...
21498297 - Baseline incidence and severity of renal insufficiency evaluated by estimated glomerula...
287547 - Prognostic significance of alkaline phosphatase measurements in patients with osteogeni...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-3
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  -     ISSN:  1651-226X     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Radiology, Oncology and Radiation Science, Department of Medical Sciences, Section of Nuclear Medicine, Uppsala University Hospital , Uppsala , Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  VB-111 for cancer.
Next Document:  Reference values for the EORTC QLQ-C30 quality of life questionnaire in a random sample of the Swedi...