| Minor Influence of Lifelong Voluntary Exercise on Composition, Structure, and Incidence of Osteoarthritis in Tibial Articular Cartilage of Mice Compared with Major Effects Caused by Growth, Maturation, and Aging. | |
| | |
MedLine Citation:
|
PMID: 21405978 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We investigated the effects of lifelong voluntary exercise on articular cartilage of mice. At the age of 4 weeks C57BL mice (n = 152) were divided into two groups, with one group serving as a sedentary control whereas the other was allowed free access to a running wheel from the age of 1 month onward. Mice were euthanized at four different time points (1, 2, 6, and 18 months of age). Articular cartilage samples were gathered from the load-bearing area of the tibial medial plateaus, and osteoarthritis was graded. Additionally, the proteoglycan content distribution was assessed using digital densitometry, collagen fibril orientation, and parallelism with polarized light microscopy, and collagen content using Fourier transform infrared imaging spectroscopy. The incidence of osteoarthritis increased with aging, but exercise had no effect on this trend. Furthermore, the structure and composition revealed significant growth, maturation, and age-dependent properties. Exercise exerted a minor effect on collagen fibril orientation in the superficial zone. Fibril orientation at 2 months of age was more perpendicular to surface (p < 0.05) in controls compared with runners, whereas the situation was reversed at the age of 18 months (p < 0.05). The collagen content of the superficial zone was higher (p < 0.01) at the age of 18 months in controls compared with runners but the proteoglycan content did not display any exercise-dependent changes. In conclusion, growth, maturation, and aging exerted a clear effect on integrity, structure, and composition of medial tibial plateau articular cartilage in mice, whereas lifelong voluntary exercise had only a minor effect on collagen architecture and content. |
| | |
Authors:
|
Tommi Närhi; Ulrika Siitonen; Lauri J Lehto; Mika M Hyttinen; Jari P A Arokoski; Pieter A Brama; Jukka S Jurvelin; Heikki J Helminen; Petro Julkunen |
Related Documents
:
|
19660118 - Effects of a probiotic soy product and physical exercise on formation of pre-neoplastic... 2132898 - Health locus of control predicts free-living, but not supervised, physical activity: a ... 15888228 - Prevalence of physical activity in the united states: behavioral risk factor surveillan... 18494188 - Physical activity related to forced vital capacity and strength performance in a sample... 8959898 - Botulinum toxin--a possible new treatment for axillary hyperhidrosis. 1150588 - Interrelationship of ffa and glycerol turnovers in resting and exercising dogs. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
|
Title: Connective tissue research Volume: - ISSN: 1607-8438 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0365263 Medline TA: Connect Tissue Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Anatomy, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Deposition of Apatite in Mineralizing Vertebrate Extracellular Matrices: A Model of Possible Nucleat...
Next Document: Characterization of Rat Apical Tissues in Different Root Development Stage.