Document Detail

Minocycline slow-release formulation effect on subgingival bacteria.
MedLine Citation:
PMID:  1552468     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine the microbiological efficacy of an adjunctive minocycline periodontal formulation delivered subgingivally. Subjects were systemically healthy but exhibited severe periodontitis; i.e., probing depths greater than 6 mm. The two study groups included individuals who received minocycline or a placebo periodontal formulation after root planing. Subgingival plaque samples were obtained at baseline; prior to treatment; and at 1, 3, and 6 months. Plaque was evaluated by darkfield microscopy and further analyzed for total dark-pigmented Bacteroides species, P. intermedia, P. gingivalis and Streptococcus, Actinomyces, Eikenella, Actinobacillus, Capnocytophaga, and Fusobacterium species using cultivable flora techniques. In addition, plaque was evaluated for yeast on a selective agar medium. When compared to the placebo, the minocycline group had significantly lower proportions of spirochetes at 1 and 3 months and lower proportions of motile rods at 3 months. Furthermore, when compared to the placebo group, the minocycline patients had lower mean proportions of dark-pigmented Bacteroides spp. and P. intermedia at 1 and 3 months as well as lower proportions of E. corrodens at 1 month. The minocycline group had significant decreases in proportions of spirochetes at 1 and 3 months, motile rods at 1 and 3 months, and increases in cocci at 1, 3, and 6 months when compared to baseline. In the placebo group, root planing was also effective at decreasing spirochetes at 1, 3, and 6 months, but with significant differences seen only at 3 and 6 months. However, the degree of reduction in spirochete proportions was greater in the minocycline group when compared with the placebo group.(ABSTRACT TRUNCATED AT 250 WORDS)
K Okuda; L Wolff; R Oliver; J Osborn; J Stoltenberg; J Bereuter; L Anderson; P Foster; N Hardie; D Aeppli
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of periodontology     Volume:  63     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  73-9     Citation Subset:  D; IM    
Department of Periodontology, Niigata University, School of Dentistry, Japan.
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MeSH Terms
Actinomyces / drug effects,  isolation & purification
Bacteria / drug effects,  isolation & purification*
Bacteroides / drug effects,  isolation & purification
Colony Count, Microbial
Delayed-Action Preparations
Dental Plaque / microbiology
Dental Scaling
Drug Implants
Middle Aged
Minocycline / administration & dosage,  therapeutic use*
Periodontal Pocket / drug therapy*,  microbiology*
Root Planing
Spirochaetales / drug effects,  isolation & purification
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Drug Implants; 0/Placebos; 10118-90-8/Minocycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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