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Minocycline-Induced Fulminant Intracranial Hypertension.
MedLine Citation:
PMID:  22490325     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To describe the clinical course of an unusually severe case of minocycline-induced intracranial hypertension. DESIGN: Case study. SETTING: Academic medical center. Patient  Twelve-year-old girl with a fulminant course of intracranial hypertension. INTERVENTIONS: Magnetic resonance imaging and venography of the brain, lumbar puncture, and optic nerve sheath fenestration. RESULTS: Although the patient ceased minocycline treatment, there was ongoing and rapid worsening of symptoms and vision loss. Lumbar puncture, which normally acts as a temporizing measure to preserve vision, failed to prevent, and may even have precipitated, further deterioration in vision, necessitating surgical intervention with optic nerve sheath fenestration. CONCLUSION: Minocycline can cause a fulminant syndrome of elevated intracranial pressure, with severe vision loss, even after the medication has been discontinued.
Authors:
Clare L Fraser; Valerie Biousse; Nancy J Newman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-9
Journal Detail:
Title:  Archives of neurology     Volume:  -     ISSN:  1538-3687     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Biousse, and Newman), Neurology (Drs Biousse and Newman), and Neurological Surgery (Dr Newman), Emory University School of Medicine, Atlanta, Georgia.
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