Document Detail


Minocycline development for acute ischemic stroke.
MedLine Citation:
PMID:  21909339     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Minocycline, a tetracycline antibiotic, has shown anti-inflammatory, anti-apoptotic, and neuroprotective effects in many models of cerebral ischemia and neurodegenerative disease. Its high penetration of the blood-brain barrier, good safety profile, and delayed therapeutic window make it an ideal candidate for use in stroke. In animal models, minocycline reduced infarct size and improved neurologic outcome when administered acutely, with similar neuroprotective benefits seen following delayed administration. To date, two early phase clinical trials have shown minocycline to be safe and potentially effective in acute ischemic stroke, alone or in combination with tissue plasminogen activator. A large efficacy clinical trial is now needed to confirm previous studies, allow for subgroup analysis, and pinpoint the potential place for minocycline in acute stroke therapy.
Authors:
Susan C Fagan; Lydia E Cronic; David C Hess
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Translational stroke research     Volume:  2     ISSN:  1868-4483     ISO Abbreviation:  Transl Stroke Res     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2013-12-10     Completed Date:  2013-12-11     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101517297     Medline TA:  Transl Stroke Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  202-8     Citation Subset:  -    
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 NS055728/NS/NINDS NIH HHS; R01 NS055728-02/NS/NINDS NIH HHS; R01 NS063965/NS/NINDS NIH HHS; R01 NS063965-03/NS/NINDS NIH HHS
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