| Minireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis. | |
MedLine Citation:
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PMID: 19389830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central GLP-1 reduces food intake and body weight. However, current research indicates that in fact, GLP-1 in each location plays a role in these functions. This review summarizes the evidence for involvement of peripheral and brain GLP-1 in food intake regulation and glucose homeostasis and proposes a model for the coordinated actions of GLP-1 at multiple sites. |
Authors:
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Diana L Williams |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2009-04-23 |
Journal Detail:
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Title: Endocrinology Volume: 150 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-24 Completed Date: 2009-07-24 Revised Date: 2014-09-09 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 2997-3001 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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metabolism* Eating Glucagon-Like Peptide 1 / physiology* Homeostasis / physiology Models, Biological Receptors, Glucagon / physiology |
| Grant Support | |
ID/Acronym/Agency:
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7K99DK078779/DK/NIDDK NIH HHS; R00 DK078779/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Receptors, Glucagon; 0/glucagon-like peptide-1 receptor; 89750-14-1/Glucagon-Like Peptide 1 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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