Document Detail


Minireview: MIRomics in Endocrinology: A Novel Approach for Modeling Endocrine Diseases.
MedLine Citation:
PMID:  23349525     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
MicroRNAs (miRNAs) are small (16-24 nucleotides) noncoding RNAs that negatively regulate gene expression. Growing evidence demonstrates that miRNAs participate in the regulation of numerous physiological and pathological processes. The clinical utility of the cell-type-specific miRNA expression profile (miRomics) has been directly demonstrated in molecular classification of tumor samples and in prediction of prognosis or therapeutic responsiveness. Identification of the relevant miRNAs and their targets requires both in silico and molecular biological methods. In this review, we summarize the methodological arsenal used in miRNA-related research, and through our own data on adrenal tumors, we present how miRNA could be integrated into omics-based networks. The expanding knowledge obtained from miRNA research may lead to the development of novel diagnostic and treatment modalities in future.
Authors:
Péter M Szabó; Henriett Butz; Péter Igaz; Károly Rácz; László Hunyady; Attila Patócs
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Molecular endocrinology (Baltimore, Md.)     Volume:  -     ISSN:  1944-9917     ISO Abbreviation:  Mol. Endocrinol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801431     Medline TA:  Mol Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Molecular Medicine Research Group (P.M.S., H.B., A.P.) and Laboratory of Molecular Physiology (L.H.), Hungarian Academy of Sciences and Semmelweis University; Second Department of Medicine (P.I., K.R.), Faculty of Medicine; and Departments of Physiology (L.H.) and Laboratory Medicine (A.P.), Faculty of Medicine, Semmelweis University, Budapest, Hungary.
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