| Delivering the code: polyplex carriers for deoxyribonucleic acid and ribonucleic acid interference therapies. | |
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MedLine Citation:
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PMID: 20032060 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleic acid-based therapies offer great potential for treatment of a variety of diseases including cancer by modulating protein expression with DNA or small interfering RNA. However, realization of their full therapeutic potential is currently limited due to an inability to reach the target site in an active form. Identification of delivery barriers such as stability in circulation, resistance to degradation and entrapment in subcellular vesicles has led to development of sophisticated multifunctional synthetic polymers for forming ionic complexes with nucleic acids and also providing performance-enhancing features. The most promising designs comprise features to help increase stability in circulation and also contain functionality to aid in endosome escape of nucleic acid cargo after cellular internalization. |
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Authors:
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R James Christie; N Nishiyama; K Kataoka |
Publication Detail:
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Type: Journal Article; Review Date: 2009-12-23 |
Journal Detail:
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Title: Endocrinology Volume: 151 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-26 Completed Date: 2010-02-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 466-73 Citation Subset: AIM; IM |
Affiliation:
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Department of Materials Engineering, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bioengineering Cross-Linking Reagents DNA / genetics*, therapeutic use Disulfides Drug Carriers Drug Delivery Systems Gene Expression Regulation Gene Therapy / methods Humans Mice Nanotechnology / methods Neoplasms / genetics, therapy RNA, Small Interfering / genetics*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cross-Linking Reagents; 0/Disulfides; 0/Drug Carriers; 0/RNA, Small Interfering; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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