Minipig urethra: A suitable animal model in vitro.  
MedLine Citation:

PMID: 23000561 Owner: NLM Status: InDataReview 
Abstract/OtherAbstract:

The study demonstrates that the minipig urethra is an appropriate animal model for in vitro experiments and therefore promising for longterm animal tests of artificial urinary sphincter systems in vivo. Freshly explanted porcine and minipig urethras were connected to a fluid reservoir that simulated the bladder pressure. This bladder pressure was adjusted by changing the water level (hydrostatic pressure). Specially designed aluminum sphincters loaded with a fluidfilled container were used to close/open the urethras. Results from minipigs and domestic pigs were compared to data published for human urethras. We measured the leakpoint pressures (LPP) by adjusting the bladder pressure at a constant sphincter length and by changing the sphincter length at a constant bladder pressure. Because the urethral tissue shows viscoelastic behavior, LPPs for both opening and closing were measured. By fitting the in vitro data, we evaluated the three characteristic parameters from the empirical urethra compression model, i.e. wall pressure (<formula>p_{W}</formula>), rim force (<formula>F_{R}</formula>), and rim length (<formula>L_{R}</formula>). From the experimental data we found agreement of mean values between (male) human urethras: <<formula>p_{W}_{opening}</formula>>= (12.9 ± 0.9) cmH<formula>_{2}</formula>O, < <formula>p_{W}_{closing}</formula>>=(8.6 ± 1.1) cmH<formula>_{2}</formula>O, <<formula>F_{R}_{opening}</formula> > =(0.06 ± 0.02) N, < <formula>F_{R}_{closing}</formula>> = (0.10 ± 0.02) N, < <formula>L_{R}_{opening}</formula>> = (3.0 ± 0.3) mm, < <formula>L_{R}_{closing}</formula>> = (5.1 ± 0.3) mm, and (male) minipig urethras: <<formula>p_{W}_{opening}</formula>>= (13.4 ± 0.3) cmH<formula>_{2}</formula>O, <<formula>p_{W}_{closing}</formula>> =(8.6 ± 0.4) cmH<formula>_{2}</formula>O, < <formula>F_{R}_{opening}</formula>> =(0.19 ± 0.01) N, <<formula>F_{R}_{closing}</formula>>= (0.21 ± 0.02) N, <<formula>L_{R}_{opening}</formula>> = (2.4 ± 0.1) mm, <<formula>L_{R}_{closing}</formula>> =(3.3 ± 1.0)~mm. These {\it in vitro} tests quantified by means of the urethra compression model demonstrate that the minipig (especially the male one) represents a suitable animal model for testing artificial urinary sphincters. 
Authors:

Daniel Joller; Shpend Mushkolaj; Javier RatiaGarcia; Florian Marti; Alexander Bachmann; Bert Müller 
Publication Detail:

Type: Journal Article 
Journal Detail:

Title: Technology and health care : official journal of the European Society for Engineering and Medicine Volume: 20 ISSN: 18787401 ISO Abbreviation: Technol Health Care Publication Date: 2012 Jan 
Date Detail:

Created Date: 20120924 Completed Date:  Revised Date:  
Medline Journal Info:

Nlm Unique ID: 9314590 Medline TA: Technol Health Care Country: Netherlands 
Other Details:

Languages: eng Pagination: 32936 Citation Subset: IM 
Affiliation:

Biomaterials Science Center, University of Basel, Basel, Switzerland. 
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