Document Detail


Minimum effectiveness of the levonorgestrel regimen of emergency contraception.
MedLine Citation:
PMID:  14720626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The standard method for estimating the effectiveness of emergency contraceptive pills (ECPs) uses external data to calculate the proportion of expected pregnancies averted by the treatment. Because these data may not be applicable to ECP study populations, this approach could result in substantial overestimation of effectiveness. We used data from two published randomized trials of the levonorgestrel and Yuzpe ECP regimens to calculate the minimum effectiveness of the levonorgestrel regimen. Conservatively assuming that the Yuzpe regimen was entirely ineffective in these trials, we estimate that the levonorgestrel regimen prevented at least 49% of expected pregnancies (95% confidence interval: 17%, 69%). Because physiologic data suggests that the Yuzpe regimen does, in fact, have some efficacy, the effectiveness of the levonorgestrel regimen is likely to be higher than our minimum estimate.
Authors:
Elizabeth Raymond; Douglas Taylor; James Trussell; Markus J Steiner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Contraception     Volume:  69     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-14     Completed Date:  2004-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-81     Citation Subset:  IM    
Affiliation:
Family Health International, PO Box 13950, Research Triangle Park, NC 27709, USA. eraymond@fhi.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Contraceptives, Oral, Synthetic / administration & dosage*,  therapeutic use
Contraceptives, Postcoital, Hormonal / administration & dosage*,  therapeutic use
Female
Humans
Levonorgestrel / administration & dosage*,  therapeutic use
Pregnancy
Randomized Controlled Trials as Topic
Treatment Outcome
Chemical
Reg. No./Substance:
0/Contraceptives, Oral, Synthetic; 0/Contraceptives, Postcoital, Hormonal; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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