| Minimum effectiveness of the levonorgestrel regimen of emergency contraception. | |
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MedLine Citation:
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PMID: 14720626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The standard method for estimating the effectiveness of emergency contraceptive pills (ECPs) uses external data to calculate the proportion of expected pregnancies averted by the treatment. Because these data may not be applicable to ECP study populations, this approach could result in substantial overestimation of effectiveness. We used data from two published randomized trials of the levonorgestrel and Yuzpe ECP regimens to calculate the minimum effectiveness of the levonorgestrel regimen. Conservatively assuming that the Yuzpe regimen was entirely ineffective in these trials, we estimate that the levonorgestrel regimen prevented at least 49% of expected pregnancies (95% confidence interval: 17%, 69%). Because physiologic data suggests that the Yuzpe regimen does, in fact, have some efficacy, the effectiveness of the levonorgestrel regimen is likely to be higher than our minimum estimate. |
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Authors:
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Elizabeth Raymond; Douglas Taylor; James Trussell; Markus J Steiner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Contraception Volume: 69 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-14 Completed Date: 2004-05-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 79-81 Citation Subset: IM |
Affiliation:
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Family Health International, PO Box 13950, Research Triangle Park, NC 27709, USA. eraymond@fhi.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Contraceptives, Oral, Synthetic / administration & dosage*, therapeutic use Contraceptives, Postcoital, Hormonal / administration & dosage*, therapeutic use Female Humans Levonorgestrel / administration & dosage*, therapeutic use Pregnancy Randomized Controlled Trials as Topic Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral, Synthetic; 0/Contraceptives, Postcoital, Hormonal; 797-63-7/Levonorgestrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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