Document Detail

Minimum detectable dose as a measure of bioassay programme capability.
MedLine Citation:
PMID:  14526994     Owner:  NLM     Status:  MEDLINE    
This paper suggests that minimum detectable dose (MDD) be used to describe the capability of bioassay programmes for which intakes are expected to be rare. This allows expression of the capability in units that correspond directly to primary dose limits. The concept uses the well established analytical statistic minimum detectable amount (MDA) as the starting point, and assumes MDA detection at a prescribed time post-intake. The resulting dose can then be used as an indication of the adequacy or capability of the programme for demonstrating compliance with the performance criteria. MDDs can be readily tabulated or plotted to demonstrate the effectiveness of different types of monitoring programmes. The inclusion of cost factors for bioassay measurements can allow optimisation.
E H Carbaugh
Related Documents :
6623484 - The mouse ciguatoxin bioassay: a dose-response curve and symptomatology analysis.
24474974 - The effect of central shielding in the dose reporting for cervical cancer in eqd2 era.
24679094 - Effect of dissolved oxygen and temperature on macromolecular composition and phb storag...
2220414 - Influence of gluten-derived fractions on chemiluminescence production by human neutroph...
10695094 - Efficacy of twice-daily amoxycillin/clavulanate in lower respiratory tract infections.
24782364 - Radiation reduction in pediatric and adult congenital patients during cardiac catheteri...
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies    
Journal Detail:
Title:  Radiation protection dosimetry     Volume:  105     ISSN:  0144-8420     ISO Abbreviation:  Radiat Prot Dosimetry     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-06     Completed Date:  2003-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109958     Medline TA:  Radiat Prot Dosimetry     Country:  England    
Other Details:
Languages:  eng     Pagination:  391-4     Citation Subset:  IM    
Pacific Northwest National Laboratory, PO Box 999, Richland, WA 99352, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Burden
Cesium Radioisotopes / analysis,  pharmacokinetics
Computer Simulation
Inhalation Exposure / analysis
Models, Biological*
North Carolina
Radiation Dosage
Radioactive Pollutants / analysis,  pharmacokinetics
Radioisotopes / analysis*,  pharmacokinetics*
Radiometry / methods*
Reproducibility of Results
Sensitivity and Specificity
Strontium Radioisotopes / analysis,  pharmacokinetics
Whole-Body Counting
Reg. No./Substance:
0/Cesium Radioisotopes; 0/Radioactive Pollutants; 0/Radioisotopes; 0/Strontium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Towards a model for the dynamic transfer of tritium and carbon in mammals.
Next Document:  Uncertainty analysis in the task of individual monitoring data.