Document Detail


Minimum detectable dose as a measure of bioassay programme capability.
MedLine Citation:
PMID:  14526994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper suggests that minimum detectable dose (MDD) be used to describe the capability of bioassay programmes for which intakes are expected to be rare. This allows expression of the capability in units that correspond directly to primary dose limits. The concept uses the well established analytical statistic minimum detectable amount (MDA) as the starting point, and assumes MDA detection at a prescribed time post-intake. The resulting dose can then be used as an indication of the adequacy or capability of the programme for demonstrating compliance with the performance criteria. MDDs can be readily tabulated or plotted to demonstrate the effectiveness of different types of monitoring programmes. The inclusion of cost factors for bioassay measurements can allow optimisation.
Authors:
E H Carbaugh
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies    
Journal Detail:
Title:  Radiation protection dosimetry     Volume:  105     ISSN:  0144-8420     ISO Abbreviation:  Radiat Prot Dosimetry     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-06     Completed Date:  2003-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109958     Medline TA:  Radiat Prot Dosimetry     Country:  England    
Other Details:
Languages:  eng     Pagination:  391-4     Citation Subset:  IM    
Affiliation:
Pacific Northwest National Laboratory, PO Box 999, Richland, WA 99352, USA. gene.carbaugh@pnl.gov
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MeSH Terms
Descriptor/Qualifier:
Body Burden
Cesium Radioisotopes / analysis,  pharmacokinetics
Computer Simulation
Humans
Inhalation Exposure / analysis
Models, Biological*
North Carolina
Radiation Dosage
Radioactive Pollutants / analysis,  pharmacokinetics
Radioisotopes / analysis*,  pharmacokinetics*
Radiometry / methods*
Reproducibility of Results
Sensitivity and Specificity
Strontium Radioisotopes / analysis,  pharmacokinetics
Whole-Body Counting
Chemical
Reg. No./Substance:
0/Cesium Radioisotopes; 0/Radioactive Pollutants; 0/Radioisotopes; 0/Strontium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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