| Minimum detectable dose as a measure of bioassay programme capability. | |
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MedLine Citation:
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PMID: 14526994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper suggests that minimum detectable dose (MDD) be used to describe the capability of bioassay programmes for which intakes are expected to be rare. This allows expression of the capability in units that correspond directly to primary dose limits. The concept uses the well established analytical statistic minimum detectable amount (MDA) as the starting point, and assumes MDA detection at a prescribed time post-intake. The resulting dose can then be used as an indication of the adequacy or capability of the programme for demonstrating compliance with the performance criteria. MDDs can be readily tabulated or plotted to demonstrate the effectiveness of different types of monitoring programmes. The inclusion of cost factors for bioassay measurements can allow optimisation. |
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Authors:
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E H Carbaugh |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies |
Journal Detail:
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Title: Radiation protection dosimetry Volume: 105 ISSN: 0144-8420 ISO Abbreviation: Radiat Prot Dosimetry Publication Date: 2003 |
Date Detail:
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Created Date: 2003-10-06 Completed Date: 2003-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109958 Medline TA: Radiat Prot Dosimetry Country: England |
Other Details:
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Languages: eng Pagination: 391-4 Citation Subset: IM |
Affiliation:
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Pacific Northwest National Laboratory, PO Box 999, Richland, WA 99352, USA. gene.carbaugh@pnl.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Body Burden Cesium Radioisotopes / analysis, pharmacokinetics Computer Simulation Humans Inhalation Exposure / analysis Models, Biological* North Carolina Radiation Dosage Radioactive Pollutants / analysis, pharmacokinetics Radioisotopes / analysis*, pharmacokinetics* Radiometry / methods* Reproducibility of Results Sensitivity and Specificity Strontium Radioisotopes / analysis, pharmacokinetics Whole-Body Counting |
| Chemical | |
Reg. No./Substance:
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0/Cesium Radioisotopes; 0/Radioactive Pollutants; 0/Radioisotopes; 0/Strontium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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