Document Detail

Minimum alveolar concentrations and hemodynamic effects of two different preparations of sevoflurane in pigs.
MedLine Citation:
PMID:  20535372     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Original sevoflurane (Sevo A) is made with water, while a generic sevoflurane (Sevocris) is produced with propylene glycol as a stabilizing additive. We investigated whether the original and generic sevoflurane preparations differed in terms of their minimum alveolar concentration (MAC) values and hemodynamic effects.
METHODS: Sixteen pigs weighing 31.6+/-1.8 kg were randomly assigned to the Sevo A or Sevocris groups. After anesthesia induction via mask with the appropriate sevoflurane preparation (6% in 100% oxygen), the MAC was determined for each animal. Hemodynamic and oxygenation parameters were measured at 0.5 MAC, 1 MAC and 1.5 MAC. Histopathological analyses of lung parenchyma were performed.
RESULTS: The MAC in the Sevo A group was 4.4+/-0.5%, and the MAC in the Sevocris group was 4.1+/-0.7%. Hemodynamic and metabolic parameters presented significant differences in a dose-dependent pattern as expected, but they did not differ between groups. Cardiac indices and arterial pressures decreased in both groups when the sevoflurane concentration increased from 0.5 to 1 and 1.5 MAC. The oxygen delivery index (DO(2)I) decreased significantly at 1.5 MAC.
CONCLUSION: Propylene glycol as an additive for sevoflurane seems to be as safe as a water additive, at least in terms of hemodynamic and pulmonary effects.
Denise A Otsuki; Denise T Fantoni; Carla Holms; Jose Otavio C Auler
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  65     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2011-04-07     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  531-7     Citation Subset:  IM    
Laboratory of Medical Investigation, LIM/08 Anesthesiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
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MeSH Terms
Anesthetics, Inhalation / chemistry,  metabolism,  pharmacology*
Blood Pressure / drug effects
Hemodynamics / drug effects*
Methyl Ethers / chemistry,  metabolism,  pharmacology*
Oxygen / metabolism
Propylene Glycol / pharmacology*
Pulmonary Alveoli / metabolism
Random Allocation
Respiration / drug effects
Time Factors
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane; 57-55-6/Propylene Glycol; 7782-44-7/Oxygen

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