| Minimum alveolar concentrations and hemodynamic effects of two different preparations of sevoflurane in pigs. | |
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MedLine Citation:
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PMID: 20535372 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Original sevoflurane (Sevo A) is made with water, while a generic sevoflurane (Sevocris) is produced with propylene glycol as a stabilizing additive. We investigated whether the original and generic sevoflurane preparations differed in terms of their minimum alveolar concentration (MAC) values and hemodynamic effects. METHODS: Sixteen pigs weighing 31.6+/-1.8 kg were randomly assigned to the Sevo A or Sevocris groups. After anesthesia induction via mask with the appropriate sevoflurane preparation (6% in 100% oxygen), the MAC was determined for each animal. Hemodynamic and oxygenation parameters were measured at 0.5 MAC, 1 MAC and 1.5 MAC. Histopathological analyses of lung parenchyma were performed. RESULTS: The MAC in the Sevo A group was 4.4+/-0.5%, and the MAC in the Sevocris group was 4.1+/-0.7%. Hemodynamic and metabolic parameters presented significant differences in a dose-dependent pattern as expected, but they did not differ between groups. Cardiac indices and arterial pressures decreased in both groups when the sevoflurane concentration increased from 0.5 to 1 and 1.5 MAC. The oxygen delivery index (DO(2)I) decreased significantly at 1.5 MAC. CONCLUSION: Propylene glycol as an additive for sevoflurane seems to be as safe as a water additive, at least in terms of hemodynamic and pulmonary effects. |
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Authors:
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Denise A Otsuki; Denise T Fantoni; Carla Holms; Jose Otavio C Auler |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinics (São Paulo, Brazil) Volume: 65 ISSN: 1980-5322 ISO Abbreviation: Clinics (Sao Paulo) Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101244734 Medline TA: Clinics (Sao Paulo) Country: Brazil |
Other Details:
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Languages: eng Pagination: 531-7 Citation Subset: IM |
Affiliation:
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Laboratory of Medical Investigation, LIM/08 Anesthesiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. |
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