Document Detail

Minimum alveolar concentration of desflurane and hemodynamic responses in neonates, infants, and children.
MedLine Citation:
PMID:  1741518     Owner:  NLM     Status:  MEDLINE    
We sought to determine the minimum alveolar concentration (MAC) and hemodynamic responses to desflurane in 72 fasting and unpremedicated full-term neonates, infants, and children up to 12 yr of age. The patients were divided into six groups (n = 12) according to age. After awake tracheal intubation, neonates were anesthetized with desflurane in oxygen and air. Infants greater than 1 month of age and all older children were anesthetized with desflurane in 100% oxygen, and their tracheas were intubated without muscle relaxation. MAC was determined using the "up-and-down technique" and logistic regression. Heart rate and systolic arterial pressure were recorded awake, at approximately 1 MAC desflurane before skin incision and at approximately 1 MAC during the peak hemodynamic responses to skin incision. We found that the relationship between MAC (mean +/- standard deviation) as determined by the up-and-down technique and age was quadratic, reaching a maximum value in infants 6-12 months of age: in neonates 0-1 month MAC was 9.16 +/- 0.02%, in infants 1-6 months 9.42 +/- 0.06%, in infants 6-12 months 9.92 +/- 0.44%, in children 1-3 yr 8.72 +/- 0.59%, in children 3-5 yr 8.62 +/- 0.45%, and in children 5-12 yr 7.98 +/- 0.43%. MAC values obtained using logistic regression were similar. Heart rate decreased an average of 16% before skin incision in infants 6-12 months of age and children 1-3 and 3-5 yr of age when compared to awake values (P less than 0.025) but did not change significantly in the remaining three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
R H Taylor; J Lerman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  75     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-01-06     Completed Date:  1992-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  975-9     Citation Subset:  AIM; IM    
Department of Anaesthesia, Hospital for Sick Children, University of Toronto, Ontario, Canada.
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MeSH Terms
Age Factors
Anesthetics / metabolism*
Blood Pressure
Child, Preschool
Heart Rate
Infant, Newborn
Isoflurane / analogs & derivatives*,  metabolism
Pulmonary Alveoli / metabolism*
Reg. No./Substance:
0/Anesthetics; 26675-46-7/Isoflurane; 57041-67-5/desflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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