| Minimum alveolar concentration of desflurane and hemodynamic responses in neonates, infants, and children. | |
| | |
MedLine Citation:
|
PMID: 1741518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We sought to determine the minimum alveolar concentration (MAC) and hemodynamic responses to desflurane in 72 fasting and unpremedicated full-term neonates, infants, and children up to 12 yr of age. The patients were divided into six groups (n = 12) according to age. After awake tracheal intubation, neonates were anesthetized with desflurane in oxygen and air. Infants greater than 1 month of age and all older children were anesthetized with desflurane in 100% oxygen, and their tracheas were intubated without muscle relaxation. MAC was determined using the "up-and-down technique" and logistic regression. Heart rate and systolic arterial pressure were recorded awake, at approximately 1 MAC desflurane before skin incision and at approximately 1 MAC during the peak hemodynamic responses to skin incision. We found that the relationship between MAC (mean +/- standard deviation) as determined by the up-and-down technique and age was quadratic, reaching a maximum value in infants 6-12 months of age: in neonates 0-1 month MAC was 9.16 +/- 0.02%, in infants 1-6 months 9.42 +/- 0.06%, in infants 6-12 months 9.92 +/- 0.44%, in children 1-3 yr 8.72 +/- 0.59%, in children 3-5 yr 8.62 +/- 0.45%, and in children 5-12 yr 7.98 +/- 0.43%. MAC values obtained using logistic regression were similar. Heart rate decreased an average of 16% before skin incision in infants 6-12 months of age and children 1-3 and 3-5 yr of age when compared to awake values (P less than 0.025) but did not change significantly in the remaining three groups.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
R H Taylor; J Lerman |
Related Documents
:
|
21699698 - Preventing childhood obesity during infancy in uk primary care: a mixed-methods study o... 1167378 - Digestibility of starches in infants and children. 18831118 - Infant welfare, philanthropy and entrepreneurship in glasgow: sister laura's infant foo... 1945548 - Clinical assessment of emotional milestones in infancy and early childhood. 12221268 - Recommendations for vitamin a supplementation. 18578898 - Anorexia nervosa trios: behavioral profiles of individuals with anorexia nervosa and th... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anesthesiology Volume: 75 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1991 Dec |
Date Detail:
|
Created Date: 1992-01-06 Completed Date: 1992-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 975-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anaesthesia, Hospital for Sick Children, University of Toronto, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Anesthetics / metabolism* Blood Pressure Child Child, Preschool Heart Rate Humans Infant Infant, Newborn Isoflurane / analogs & derivatives*, metabolism Pulmonary Alveoli / metabolism* Systole |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics; 26675-46-7/Isoflurane; 57041-67-5/desflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pharmacokinetics of amrinone during cardiac surgery.
Next Document: Effects of partial paralysis on the swallowing reflex in conscious humans.