Document Detail

Minimizing therapeutically induced anemia.
MedLine Citation:
PMID:  7328364     Owner:  NLM     Status:  MEDLINE    
A model for erythroid production based on a continuous maturation-proliferation scheme is developed. The model includes a simple control mechanism operating at the proliferating cell level, and analytic solutions for the time dependent response of the model are derived. Using this model, the response of the erythron to a massive depletion of the proliferating cell compartment (due for example to cytostatic drugs or radiation) is calculated. It is demonstrated that a therapeutic measure designed to decrease the erythroid precursor maturation velocity may considerably ameliorated the deleterious effects of proliferating cell destruction. One way to decrease the erythroid cell maturation rate would be by having the patient breathe in an oxygen enriched atmosphere.
A Lasota; M C Mackey; M Wazewska-Czyzewska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of mathematical biology     Volume:  13     ISSN:  0303-6812     ISO Abbreviation:  J Math Biol     Publication Date:  1981  
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7502105     Medline TA:  J Math Biol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  149-58     Citation Subset:  IM    
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MeSH Terms
Anemia / blood,  chemically induced*,  therapy
Antineoplastic Agents / adverse effects
Cell Division / drug effects
Erythrocytes / drug effects*,  pathology
Hematopoietic Stem Cells / drug effects,  pathology
Models, Biological*
Oxygen Inhalation Therapy
Reg. No./Substance:
0/Antineoplastic Agents

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