Document Detail

Minimizing risk of adverse reactions to mydriatic agents in binocular indirect ophthalmoscopy.
MedLine Citation:
PMID:  4020007     Owner:  NLM     Status:  MEDLINE    
To minimize the risk of adverse side effects from mydriatics during binocular indirect ophthalmoscopy, a procedure was developed which intentionally starts with a dose significantly less than an ED99. Using a clinically effective diameter of greater than 7 mm as a criterion, I found that 1 drop of 0.5% tropicamide (T) constituted an ED74 (N = 46). When 1 drop of 2.5% phenylephrine (P) was added, this increased to an ED93 (N = 27). If present results can be generalized, then 1 drop of T, supplemented at 30 minutes with 1 drop of P, if necessary, should produce satisfactory dilatation in approximately 90% of the subjects.
L Levine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Optometric Association     Volume:  56     ISSN:  0003-0244     ISO Abbreviation:  J Am Optom Assoc     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-09-17     Completed Date:  1985-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505575     Medline TA:  J Am Optom Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  542-8     Citation Subset:  IM    
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MeSH Terms
Drug Evaluation
Mydriatics / adverse effects*,  diagnostic use
Ophthalmic Solutions
Ophthalmoscopy / methods*
Phenylephrine / administration & dosage,  diagnostic use
Pupil / drug effects
Tropicamide / administration & dosage,  diagnostic use
Reg. No./Substance:
0/Mydriatics; 0/Ophthalmic Solutions; 1508-75-4/Tropicamide; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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