| Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes. | |
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MedLine Citation:
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PMID: 16782081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the minimally modified electronegative LDL (LDL-) and its autoantibodies in coronary syndromes. DESIGN AND METHODS: LDL(-) and its autoantibodies were determined by ELISA in patients with acute (ACS, unstable angina; AMI, acute myocardial infarction) and chronic coronary syndromes (stable angina, SA) and compared to subjects without coronary disease (controls). Results are expressed as median of LDL- (microg/mL) and anti-LDL(-) IgG (OD405 nm). RESULTS: The concentrations of LDL(-) were higher in patients with coronary disease (ACS: 40.7 microg/mL; SA: 35.0 microg/mL) as compared to controls (21.6 microg/mL). The highest LDL- concentrations were found in patients with AMI (41.8 microg/mL). Anti-LDL(-) IgG was elevated in ACS (1.143) in relation to CCS (0.527) and controls (0.467). A positive correlation was observed between anti-LDL- IgG and CRP levels (r = 0.34, p <0.01) in the studied groups. CONCLUSIONS: LDL(-) and anti-LDL(-) autoantibodies may be useful markers to follow patients with high risk for coronary events. |
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Authors:
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Jair A Oliveira; Alex Sevanian; Ricardo J Rodrigues; Elaine Apolinário; Dulcineia S P Abdalla |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-05-19 |
Journal Detail:
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Title: Clinical biochemistry Volume: 39 ISSN: 0009-9120 ISO Abbreviation: Clin. Biochem. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-17 Completed Date: 2006-08-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 708-14 Citation Subset: IM |
Affiliation:
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Centro de Ciências da Saúde, Universidade Estadual de Londrina, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged, 80 and over Angina, Unstable / blood, immunology Autoantibodies / analysis*, blood Biological Markers / analysis* Case-Control Studies Coronary Artery Disease / blood, immunology Coronary Disease / blood*, immunology Female Humans Lipoproteins, LDL / chemistry*, immunology* Male Middle Aged Myocardial Infarction / blood, immunology Predictive Value of Tests |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Biological Markers; 0/Lipoproteins, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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