Document Detail


Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes.
MedLine Citation:
PMID:  16782081     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine the minimally modified electronegative LDL (LDL-) and its autoantibodies in coronary syndromes. DESIGN AND METHODS: LDL(-) and its autoantibodies were determined by ELISA in patients with acute (ACS, unstable angina; AMI, acute myocardial infarction) and chronic coronary syndromes (stable angina, SA) and compared to subjects without coronary disease (controls). Results are expressed as median of LDL- (microg/mL) and anti-LDL(-) IgG (OD405 nm). RESULTS: The concentrations of LDL(-) were higher in patients with coronary disease (ACS: 40.7 microg/mL; SA: 35.0 microg/mL) as compared to controls (21.6 microg/mL). The highest LDL- concentrations were found in patients with AMI (41.8 microg/mL). Anti-LDL(-) IgG was elevated in ACS (1.143) in relation to CCS (0.527) and controls (0.467). A positive correlation was observed between anti-LDL- IgG and CRP levels (r = 0.34, p <0.01) in the studied groups. CONCLUSIONS: LDL(-) and anti-LDL(-) autoantibodies may be useful markers to follow patients with high risk for coronary events.
Authors:
Jair A Oliveira; Alex Sevanian; Ricardo J Rodrigues; Elaine Apolinário; Dulcineia S P Abdalla
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-19
Journal Detail:
Title:  Clinical biochemistry     Volume:  39     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-17     Completed Date:  2006-08-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  708-14     Citation Subset:  IM    
Affiliation:
Centro de Ciências da Saúde, Universidade Estadual de Londrina, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged, 80 and over
Angina, Unstable / blood,  immunology
Autoantibodies / analysis*,  blood
Biological Markers / analysis*
Case-Control Studies
Coronary Artery Disease / blood,  immunology
Coronary Disease / blood*,  immunology
Female
Humans
Lipoproteins, LDL / chemistry*,  immunology*
Male
Middle Aged
Myocardial Infarction / blood,  immunology
Predictive Value of Tests
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/Lipoproteins, LDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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