| Minimally invasive input function for 2-(18)F-fluoro-A-85380 brain PET studies. | |
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MedLine Citation:
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PMID: 22231015 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Quantitative neuroreceptor positron emission tomography (PET) studies often require arterial cannulation to measure input function. While population-based input function (PBIF) would be a less invasive alternative, it has only rarely been used in conjunction with neuroreceptor PET tracers. The aims of this study were (1) to validate the use of PBIF for 2-(18)F-fluoro-A-85380, a tracer for nicotinic receptors; (2) to compare the accuracy of measures obtained via PBIF to those obtained via blood-scaled image-derived input function (IDIF) from carotid arteries; and (3) to explore the possibility of using venous instead of arterial samples for both PBIF and IDIF. METHODS: Ten healthy volunteers underwent a dynamic 2-(18)F-fluoro-A-85380 brain PET scan with arterial and, in seven subjects, concurrent venous serial blood sampling. PBIF was obtained by averaging the normalized metabolite-corrected arterial input function and subsequently scaling each curve with individual blood samples. IDIF was obtained from the carotid arteries using a blood-scaling method. Estimated Logan distribution volume (V (T)) values were compared to the reference values obtained from arterial cannulation. RESULTS: For all subjects, PBIF curves scaled with arterial samples were similar in shape and magnitude to the reference arterial input function. The Logan V (T) ratio was 1.00 ± 0.05; all subjects had an estimation error <10%. IDIF gave slightly less accurate results (V (T) ratio 1.03 ± 0.07; eight of ten subjects had an error <10%). PBIF scaled with venous samples yielded inaccurate results (V (T) ratio 1.13 ± 0.13; only three of seven subjects had an error <10%). Due to arteriovenous differences at early time points, IDIF could not be calculated using venous samples. CONCLUSION: PBIF scaled with arterial samples accurately estimates Logan V (T) for 2-(18)F-fluoro-A-85380. Results obtained with PBIF were slightly better than those obtained with IDIF. Due to arteriovenous concentration differences, venous samples cannot be substituted for arterial samples. |
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Authors:
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Paolo Zanotti-Fregonara; Renaud Maroy; Marie-Anne Peyronneau; Régine Trebossen; Michel Bottlaender |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: - ISSN: 1619-7089 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Molecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, MSC-1026, Bethesda, MD, 20892-2035, USA, zanottifregonp@mail.nih.gov. |
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