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Minimally invasive input function for 2-(18)F-fluoro-A-85380 brain PET studies.
MedLine Citation:
PMID:  22231015     Owner:  NLM     Status:  Publisher    
PURPOSE: Quantitative neuroreceptor positron emission tomography (PET) studies often require arterial cannulation to measure input function. While population-based input function (PBIF) would be a less invasive alternative, it has only rarely been used in conjunction with neuroreceptor PET tracers. The aims of this study were (1) to validate the use of PBIF for 2-(18)F-fluoro-A-85380, a tracer for nicotinic receptors; (2) to compare the accuracy of measures obtained via PBIF to those obtained via blood-scaled image-derived input function (IDIF) from carotid arteries; and (3) to explore the possibility of using venous instead of arterial samples for both PBIF and IDIF. METHODS: Ten healthy volunteers underwent a dynamic 2-(18)F-fluoro-A-85380 brain PET scan with arterial and, in seven subjects, concurrent venous serial blood sampling. PBIF was obtained by averaging the normalized metabolite-corrected arterial input function and subsequently scaling each curve with individual blood samples. IDIF was obtained from the carotid arteries using a blood-scaling method. Estimated Logan distribution volume (V (T)) values were compared to the reference values obtained from arterial cannulation. RESULTS: For all subjects, PBIF curves scaled with arterial samples were similar in shape and magnitude to the reference arterial input function. The Logan V (T) ratio was 1.00 ± 0.05; all subjects had an estimation error <10%. IDIF gave slightly less accurate results (V (T) ratio 1.03 ± 0.07; eight of ten subjects had an error <10%). PBIF scaled with venous samples yielded inaccurate results (V (T) ratio 1.13 ± 0.13; only three of seven subjects had an error <10%). Due to arteriovenous differences at early time points, IDIF could not be calculated using venous samples. CONCLUSION: PBIF scaled with arterial samples accurately estimates Logan V (T) for 2-(18)F-fluoro-A-85380. Results obtained with PBIF were slightly better than those obtained with IDIF. Due to arteriovenous concentration differences, venous samples cannot be substituted for arterial samples.
Paolo Zanotti-Fregonara; Renaud Maroy; Marie-Anne Peyronneau; Régine Trebossen; Michel Bottlaender
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-10
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  -     ISSN:  1619-7089     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Molecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, MSC-1026, Bethesda, MD, 20892-2035, USA,
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