| Minimally invasive closure of pediatric umbilical hernias. | |
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MedLine Citation:
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PMID: 18206469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pediatric umbilical hernias may close spontaneously by concentric fibrosis and scar tissue formation. Some hernias do not close. This study was developed to assess this novel minimally invasive closure (MIC), using injectable material to close the umbilical defect. METHOD: Twenty-five children with umbilical hernias of 1.5 cm or less were included in the study. Deflux (Q Med, Uppsala, Sweden), a biodegradable compound of dextranomer microspheres in hyaluronic acid, was injected percutaneously in the border and preperitoneal space in 4 quadrants of the hernia defect, thereby occluding the lumen. Follow-up visits were obtained at approximately 1 week, 3 months, and 1 year. RESULTS: Two to twenty-four months after surgery, 21 of the 25 umbilical hernias were closed (84%). To date, there have been no complications from the injected compound substance. The average age at the time of the MIC was 6 years and 7 months, ranging from 4 months to 17 years. The average defect was more than 6.4 mm, ranging from 4 to 14 mm. CONCLUSION: Minimally invasive closure procedure with injection of dextranomer hyaluronic acid copolymer can safely be used to close umbilical hernias. The procedure closed or reduced the size of hernias in our patients immediately after surgery; and within months, 21 (84%) of 25 were closed. One defect has not closed in 1 year and will need repair. The remaining 3 defects are small and may go on to close by ongoing fibroblast ingrowth and collagen deposit. The MIC procedure may be an alternative to open repair of umbilical hernias. Increased experience and long-term follow-up will determine the true efficacy of this new technique. |
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Authors:
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Neil R Feins; Alexander Dzakovic; Konstantinos Papadakis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 43 ISSN: 1531-5037 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-21 Completed Date: 2008-02-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: United States |
Other Details:
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Languages: eng Pagination: 127-30 Citation Subset: IM |
Affiliation:
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Department of Pediatric Surgery, Children's Hospital Boston, Boston, MA 02115, USA. neil.feins@childrens.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Cohort Studies Dextrans / therapeutic use* Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Hernia, Umbilical / diagnosis, therapy* Humans Hyaluronic Acid / therapeutic use* Infant Injections, Intralesional Male Risk Assessment Surgical Procedures, Minimally Invasive / methods Tensile Strength Treatment Outcome Wound Healing / physiology |
| Chemical | |
Reg. No./Substance:
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56087-11-7/dextranomer; 9004-54-0/Dextrans; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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