| A minimally invasive treatment for lumbar disc herniation: DiscoGel® chemonucleolysis in patients unresponsive to chemonucleolysis with oxygen-ozone. | |
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MedLine Citation:
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PMID: 22440607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A multitude of therapies is available to treat disc herniation, ranging from conservative methods (medication and physical therapy) to minimally invasive (percutaneous) treatments and surgery. O₂-O₃ chemonucleolysis (O₂-O₃ therapy) is one of the minimally invasive treatments with the best cost/benefit ratio and lowest complication rate. Another substance recently made available exploiting the chemical properties of pure ethanol is DiscoGel®, a radiopaque gelified ethanol more viscous than absolute alcohol 8,9. The present study aimed to assess the therapeutic outcome of DiscoGel® chemonucleolysis in patients with lumbar disc herniation unresponsive to O₂-O₃ therapy. Thirty-two patients aged between 20 and 79 years were treated by DiscoGel® chemonucleolysis between December 2008 and January 2010. The treatment was successful (improvement in pain) in 24 out of 32 patients. DiscoGel® is safe and easy to handle and there were no complications related to product diffusivity outside the treatment site. The therapeutic success rate of DiscoGel® chemonucleolysis in patients unresponsive to O₂-O₃ therapy was satisfactory. Among other methods used to treat lumbar disc herniation, DiscoGel® chemonucleolysis can be deemed an intermediate procedure bridging conservative medical treatments and surgery. |
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Authors:
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S Stagni; F de Santis; L Cirillo; M Dall'olio; C Princiotta; L Simonetti; A Stafa; M Leonardi |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2012-03-16 |
Journal Detail:
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Title: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences Volume: 18 ISSN: 1591-0199 ISO Abbreviation: Interv Neuroradiol Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-23 Completed Date: 2012-05-29 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 9602695 Medline TA: Interv Neuroradiol Country: Italy |
Other Details:
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Languages: eng Pagination: 97-104 Citation Subset: IM |
Affiliation:
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Department of Neuroradiology, IRCCS delle Scienze Neurologiche, Ospedale Bellaria, University of Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Drug Resistance Ethanol / therapeutic use* Gels / therapeutic use Humans Intervertebral Disc Chemolysis / methods* Intervertebral Disc Displacement / radiography, therapy* Lumbar Vertebrae Middle Aged Needles Oxygen / administration & dosage Ozone / administration & dosage Solvents / therapeutic use Surgical Procedures, Minimally Invasive / methods* Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Gels; 0/Solvents; 10028-15-6/Ozone; 64-17-5/Ethanol; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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