Document Detail

A minimally invasive treatment for lumbar disc herniation: DiscoGel® chemonucleolysis in patients unresponsive to chemonucleolysis with oxygen-ozone.
MedLine Citation:
PMID:  22440607     Owner:  NLM     Status:  MEDLINE    
A multitude of therapies is available to treat disc herniation, ranging from conservative methods (medication and physical therapy) to minimally invasive (percutaneous) treatments and surgery. O₂-O₃ chemonucleolysis (O₂-O₃ therapy) is one of the minimally invasive treatments with the best cost/benefit ratio and lowest complication rate. Another substance recently made available exploiting the chemical properties of pure ethanol is DiscoGel®, a radiopaque gelified ethanol more viscous than absolute alcohol 8,9. The present study aimed to assess the therapeutic outcome of DiscoGel® chemonucleolysis in patients with lumbar disc herniation unresponsive to O₂-O₃ therapy. Thirty-two patients aged between 20 and 79 years were treated by DiscoGel® chemonucleolysis between December 2008 and January 2010. The treatment was successful (improvement in pain) in 24 out of 32 patients. DiscoGel® is safe and easy to handle and there were no complications related to product diffusivity outside the treatment site. The therapeutic success rate of DiscoGel® chemonucleolysis in patients unresponsive to O₂-O₃ therapy was satisfactory. Among other methods used to treat lumbar disc herniation, DiscoGel® chemonucleolysis can be deemed an intermediate procedure bridging conservative medical treatments and surgery.
S Stagni; F de Santis; L Cirillo; M Dall'olio; C Princiotta; L Simonetti; A Stafa; M Leonardi
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2012-03-16
Journal Detail:
Title:  Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences     Volume:  18     ISSN:  1591-0199     ISO Abbreviation:  Interv Neuroradiol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-23     Completed Date:  2012-05-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9602695     Medline TA:  Interv Neuroradiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  97-104     Citation Subset:  IM    
Department of Neuroradiology, IRCCS delle Scienze Neurologiche, Ospedale Bellaria, University of Bologna, Italy.
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MeSH Terms
Drug Resistance
Ethanol / therapeutic use*
Gels / therapeutic use
Intervertebral Disc Chemolysis / methods*
Intervertebral Disc Displacement / radiography,  therapy*
Lumbar Vertebrae
Middle Aged
Oxygen / administration & dosage
Ozone / administration & dosage
Solvents / therapeutic use
Surgical Procedures, Minimally Invasive / methods*
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Gels; 0/Solvents; 10028-15-6/Ozone; 64-17-5/Ethanol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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