Document Detail

Minimal whey protein with carbohydrate stimulates muscle protein synthesis following resistance exercise in trained young men.
MedLine Citation:
PMID:  18059587     Owner:  NLM     Status:  MEDLINE    
Whey protein is a supplemental protein source often used by athletes, particularly those aiming to gain muscle mass; however, direct evidence for its efficacy in stimulating muscle protein synthesis (MPS) is lacking. We aimed to determine the impact of consuming whey protein on skeletal muscle protein turnover in the post-exercise period. Eight healthy resistance-trained young men (age=21+/-1 .0 years; BMI=26.8+/-0.9 kg/m2 (means+/-SE)) participated in a double-blind randomized crossover trial in which they performed a unilateral leg resistance exercise workout (EX: 4 sets of knee extensions and 4 sets of leg press; 8-10 repetitions/set; 80% of maximal), such that one leg was not exercised and acted as a rested (RE) comparator. After exercise, subjects consumed either an isoenergetic whey protein plus carbohydrate beverage (WHEY: 10 g protein and 21 g fructose) or a carbohydrate-only beverage (CHO: 21 g fructose and 10 g maltodextran). Subjects received pulse-tracer injections of L-[ring-2H5]phenylalanine and L-[15N]phenylalanine to measure MPS. Exercise stimulated a rise in MPS in the WHEY-EX and CHO-EX legs, which were greater than MPS in the WHEY-RE leg and the CHO-RE leg (all p<0.05), respectively. The rate of MPS in the WHEY-EX leg was greater than in the CHO-EX leg (p<0.001). We conclude that a small dose (10 g) of whey protein with carbohydrate (21 g) can stimulate a rise in MPS after resistance exercise in trained young men that would be supportive of a positive net protein balance, which, over time, would lead to hypertrophy.
Jason E Tang; Joshua J Manolakos; Greg W Kujbida; Paul J Lysecki; Daniel R Moore; Stuart M Phillips
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  32     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1132-8     Citation Subset:  IM    
Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada.
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MeSH Terms
Blood Glucose / metabolism
Dietary Carbohydrates / pharmacology*
Exercise / physiology*
Insulin / blood
Milk Proteins / pharmacology*
Muscle Proteins / biosynthesis*
Muscle, Skeletal / drug effects*,  metabolism,  physiology*
Phenylalanine / metabolism
Weight Lifting / physiology*
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Milk Proteins; 0/Muscle Proteins; 0/whey protein; 11061-68-0/Insulin; 63-91-2/Phenylalanine

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