Document Detail

Minimal stimulation with simplified monitoring for in vitro fertilization.
MedLine Citation:
PMID:  7795368     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This retrospective, descriptive study was designed to determine the effectiveness of using clomiphene citrate in relatively high daily doses (100, 150, and 200 mg) with simplified monitoring for in vitro fertilization in a private office and surgical center. The self-selected study population comprised 109 women who were 25-42 years old, including 26 women whose husbands had mild male-factor infertility. RESULTS: During January 1992 through December 1993, 165 stimulation cycles resulted in 137 egg retrievals, 24 clinical pregnancies (17.5%), and 20 viable pregnancies (14.5%). Cycles that could not be completed (28/165 or 16.9% of all cycles) involved luteinizing hormone surges, insufficient follicles, or low estradiol levels. There were no pregnancies in patients who were 40 years or older or who received 200 mg daily doses of clomiphene citrate. The viable pregnancy rate among patients with male factor infertility was 7.7% (2/26). For non-male-factor infertility patients who were younger than 40, the viable pregnancy rate was 17.6% (18/102). CONCLUSION: The simplified monitoring method did not appear to compromise the results.
J B Massey; P E Ingargiola; M J Tucker; D E Mitchell-Leef; G Wright
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  11     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-07-31     Completed Date:  1995-07-31     Revised Date:  2008-03-18    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  353-8     Citation Subset:  IM    
Reproductive Biology Associates, Atlanta, Georgia 30342, USA.
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MeSH Terms
Biological Markers / urine
Chorionic Gonadotropin / therapeutic use
Clomiphene / therapeutic use*
Dose-Response Relationship, Drug
Embryo Transfer
Fertilization in Vitro*
Infertility, Male / physiopathology
Luteinizing Hormone / urine*
Menstrual Cycle
Monitoring, Physiologic / methods*
Ovarian Follicle / ultrasonography
Pregnancy Outcome
Private Practice
Retrospective Studies
Self Care
Spermatozoa / physiology
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 9002-67-9/Luteinizing Hormone; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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