| Minimal residual disease testing in acute leukemia by flow cytometry immunophenotyping: prognostic significance. | |
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MedLine Citation:
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PMID: 17353179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two main techniques are being used for the detection of minimal residual disease (MRD) in acute leukemia (AL): immunophenotypic analysis and polymerase chain reaction (PCR). In this paper, we analyze the results of assessing MRD by means of flow cytometry (FC) in a group of 93 patients with AL who were prospectively studied and treated in a single institution over a 9-year period. The presence or absence of MRD was established at a cut-off level of 2%, as judged by FC; a single result above this level was considered to define the positivity. The patients were grouped in 4 subsets: (1) acute lymphoblastic leukemia (ALL) patients with MRD (n = 36); (2) acute myeloblastic leukemia (AML) patients with MRD (n = 13); (3) ALL patients without MRD (n = 31); and (4) AML patients without MRD (n = 13). The relapse rates in these groups were 17%, 8%, 0%, and 0%, respectively, whereas the overall 7-year survival was 65%, 69%, 83%, and 98%, respectively. Our results support the usefulness of serially assessing MRD in patients with AL by means of FC; because this method is applicable to all cases of AL, despite being less sensitive than a molecular biology study; it is a good option to follow-up patients and to decide therapeutic and timely interventions. |
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Authors:
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Guillermo J Ruiz-Argüelles; Danitza Fernández-Lara; Roberto Estrada-Gómez; Carlos Manzano; Guillermo J Ruiz-Delgado; Beatriz Pérez-Romano; Alejandro Ruiz-Argüelles |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Laboratory hematology : official publication of the International Society for Laboratory Hematology Volume: 13 ISSN: 1080-2924 ISO Abbreviation: Lab Hematol Publication Date: 2007 |
Date Detail:
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Created Date: 2007-03-13 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9615688 Medline TA: Lab Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 22-6 Citation Subset: IM |
Affiliation:
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Centro de Hematología y Medicina Interna de Puebla, Puebla, Mexico. gruiz1@clinicaruiz.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Biological Markers / blood Child Child, Preschool Flow Cytometry Humans Infant Leukemia, Myeloid, Acute / blood* Longitudinal Studies Middle Aged Neoplasm Recurrence, Local / blood* Neoplasm, Residual / blood*, diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood* Predictive Value of Tests Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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