| Minimal ovarian stimulation (mini-IVF) for IVF utilizing vitrification and cryopreserved embryo transfer. | |
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MedLine Citation:
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PMID: 20810320 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gentle ovarian stimulation protocols, such as 'mini-IVF', have several potential advantages over conventional IVF protocols, including less medication and fewer injections, producing fewer eggs, but eggs of higher quality. The particular 'mild' stimulation protocol called 'mini-IVF' is described. This protocol requires a reliable and cheap method for embryo cryopreservation such as vitrification, because of the negative impact of clomiphene citrate on the endometrium and since cryopreserved embryo transfers with this protocol have yielded much higher pregnancy rates than fresh transfers. In this series, patients were not denied treatment based on their day-3 FSH value or ovarian reserve. Yet very acceptable pregnancy rates were achieved (20% for fresh embryo transfers and 41% for cryopreserved embryo transfers). These results strengthen the argument for a mini-IVF protocol and vitrification as an alternative to standard conventional IVF stimulation protocols. Now a randomized control trial with cryopreserved single-embryo transfer is required. |
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Authors:
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John Zhang; Lyndon Chang; Yoshie Sone; Sherman Silber |
Publication Detail:
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Type: Journal Article Date: 2010-06-30 |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 21 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-13 Revised Date: 2011-10-13 |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: Netherlands |
Other Details:
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Languages: eng Pagination: 485-95 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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New Hope Fertility Center, New York, NY 10021, USA. soneyoshie@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clomiphene / therapeutic use Cryopreservation Embryo Transfer / methods* Female Humans Middle Aged Ovulation Induction / methods* Pregnancy Pregnancy Rate Vitrification |
| Chemical | |
Reg. No./Substance:
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911-45-5/Clomiphene |
| Comments/Corrections | |
Comment In:
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Reprod Biomed Online. 2011 Sep;23(3):274-8
[PMID:
21802365
]
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Erratum In:
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Reprod Biomed Online. 2011 Sep;23(3):396 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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