| Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough? | |
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MedLine Citation:
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PMID: 10837305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Parenterally nourished preterm infants commonly receive minimal enteral feedings, the aim being to enhance intestinal function. Whether this regimen increases intestinal growth has not been established. OBJECTIVE: Our objective was to determine the minimal enteral nutrient intakes necessary to stimulate and to normalize neonatal intestinal growth. METHODS: Intestinal growth and cell proliferation were quantified in neonatal pigs given equal amounts of an elemental nutrient solution for 7 d. Different groups (n = 5-7 per group) received 0%, 10%, 20%, 40%, 60%, 80%, or 100% of total nutrient intake enterally, with the remainder given parenterally. RESULTS: In the jejunum, wet weight, protein mass, and villus height were significantly greater at enteral intakes >40%. Stimulation of ileal protein mass required a higher enteral intake (60%). In both segments, abrupt increases in DNA mass, crypt depth, ornithine decarboxylase activity, and crypt cells in S-phase occurred between enteral intakes of 40% and 60%. Circulating concentrations of glucagon-like peptide-2 and peptide YY, but not gastrin, increased significantly between enteral intakes of 40% and 60% and closely paralleled indexes of cell proliferation. CONCLUSIONS: The minimal enteral nutrient intake necessary to increase mucosal mass was 40% of total nutrient intake, whereas 60% enteral nutrition was necessary to sustain normal mucosal proliferation and growth. Our results imply that providing <40% of the total nutrient intake enterally does not have significant intestinal trophic effects. |
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Authors:
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D G Burrin; B Stoll; R Jiang; X Chang; B Hartmann; J J Holst; G H Greeley; P J Reeds |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 71 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-07-14 Completed Date: 2000-07-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1603-10 Citation Subset: AIM; IM |
Affiliation:
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US Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. dburrin@bcm.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / growth & development* Cell Division DNA / analysis Enteral Nutrition* Food, Formulated Gastrins / blood Glucagon-Like Peptide 2 Glucagon-Like Peptides Ileum / growth & development Intestines / growth & development* Jejunum / growth & development Nutritional Requirements* Organ Size Peptide YY / blood Peptides / blood Proteins / analysis Swine Weight Gain |
| Grant Support | |
ID/Acronym/Agency:
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R01HD33920/HD/NICHD NIH HHS; R01HD35679/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 0/Glucagon-Like Peptide 2; 0/Peptides; 0/Proteins; 106388-42-5/Peptide YY; 62340-29-8/Glucagon-Like Peptides; 9007-49-2/DNA |
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