Document Detail


Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough?
MedLine Citation:
PMID:  10837305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Parenterally nourished preterm infants commonly receive minimal enteral feedings, the aim being to enhance intestinal function. Whether this regimen increases intestinal growth has not been established. OBJECTIVE: Our objective was to determine the minimal enteral nutrient intakes necessary to stimulate and to normalize neonatal intestinal growth. METHODS: Intestinal growth and cell proliferation were quantified in neonatal pigs given equal amounts of an elemental nutrient solution for 7 d. Different groups (n = 5-7 per group) received 0%, 10%, 20%, 40%, 60%, 80%, or 100% of total nutrient intake enterally, with the remainder given parenterally. RESULTS: In the jejunum, wet weight, protein mass, and villus height were significantly greater at enteral intakes >40%. Stimulation of ileal protein mass required a higher enteral intake (60%). In both segments, abrupt increases in DNA mass, crypt depth, ornithine decarboxylase activity, and crypt cells in S-phase occurred between enteral intakes of 40% and 60%. Circulating concentrations of glucagon-like peptide-2 and peptide YY, but not gastrin, increased significantly between enteral intakes of 40% and 60% and closely paralleled indexes of cell proliferation. CONCLUSIONS: The minimal enteral nutrient intake necessary to increase mucosal mass was 40% of total nutrient intake, whereas 60% enteral nutrition was necessary to sustain normal mucosal proliferation and growth. Our results imply that providing <40% of the total nutrient intake enterally does not have significant intestinal trophic effects.
Authors:
D G Burrin; B Stoll; R Jiang; X Chang; B Hartmann; J J Holst; G H Greeley; P J Reeds
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  71     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-14     Completed Date:  2000-07-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1603-10     Citation Subset:  AIM; IM    
Affiliation:
US Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. dburrin@bcm.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / growth & development*
Cell Division
DNA / analysis
Enteral Nutrition*
Food, Formulated
Gastrins / blood
Glucagon-Like Peptide 2
Glucagon-Like Peptides
Ileum / growth & development
Intestines / growth & development*
Jejunum / growth & development
Nutritional Requirements*
Organ Size
Peptide YY / blood
Peptides / blood
Proteins / analysis
Swine
Weight Gain
Grant Support
ID/Acronym/Agency:
R01HD33920/HD/NICHD NIH HHS; R01HD35679/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Gastrins; 0/Glucagon-Like Peptide 2; 0/Peptides; 0/Proteins; 106388-42-5/Peptide YY; 62340-29-8/Glucagon-Like Peptides; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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