| Minimal change nephrotic syndrome with stiff-person syndrome: is there a link? | |
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MedLine Citation:
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PMID: 15983949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stiff-person syndrome is a rare, likely immune-mediated neurological disorder characterized by painful spasms and progressive symmetric rigidity of the axial and proximal limb muscles. Rigidity of truncal muscles and continuous contraction of the agonist and antagonist muscles caused by involuntary motor-unit firing at rest are the hallmarks of stiff-person syndrome. Immunosuppressive therapy has induced remission in patients with stiff-person syndrome. We report a patient with stiff-person syndrome with minimal change nephrotic syndrome (MCNS). The pathophysiologic states of stiff-person syndrome and MCNS are unclear. T-Cell-dependent mechanisms are highly suspected for the pathogenesis of both. The diagnosis of stiff-person syndrome was made on the basis of clinical and laboratory findings, and both MCNS and stiff-person syndrome resolved completely with immunosuppressive therapy. To our knowledge, this is the first case of stiff-person syndrome in association with MCNS in the literature. |
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Authors:
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Ihsan Ergün; M Cenk Akbostanci; Başol Canbakan; Bilge Koçer; Arzu Ensari; Gökhan Nergizoglu; Kenan Keven |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 46 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-28 Completed Date: 2005-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: e11-4 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Ankara University School of Medicine, Ibni Sina Hospital, Ankara, Turkey. ihsanerg@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cyclophosphamide / therapeutic use Diazepam / therapeutic use Drug Therapy, Combination Electromyography Humans Immunity, Cellular Immunosuppressive Agents / therapeutic use Male Methylprednisolone / therapeutic use Muscle Relaxants, Central / therapeutic use Nephrosis, Lipoid / complications*, drug therapy, immunology Nephrotic Syndrome / drug therapy, etiology*, immunology Prednisolone / therapeutic use Remission Induction Stiff-Person Syndrome / diagnosis, drug therapy, etiology*, immunology, physiopathology T-Lymphocyte Subsets / immunology |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Muscle Relaxants, Central; 439-14-5/Diazepam; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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