| Minimal alpha 1- and alpha 2-adrenoceptor-mediated coronary vasoconstriction in the anaesthetized swine. | |
| | |
MedLine Citation:
|
PMID: 1979425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
alpha-Adrenoceptor-mediated coronary vasoconstriction contributes to the initiation and aggravation of experimental and clinical myocardial ischaemia. However, the extent of alpha 1- and alpha 2-adrenoceptor-mediated constriction has not been characterized in the porcine coronary circulation despite the frequent use of this experimental model. Fifteen swine were anaesthetized with either alpha-chloralose, enflurane or isoflurane to determine the amount of alpha-adrenoceptor-mediated coronary constriction elicited by either the selective alpha 1-adrenoceptor agonist methoxamine or the selective alpha 2-adrenoceptor agonist azepexole. The left anterior descending coronary artery was cannulated and perfused by an external pump delivering constant blood flow from the carotid artery. Following bilateral cervical vagotomy and beta-adrenoceptor blockade with propranolol (2 mg kg-1), graded dosages of either one of the alpha-adrenoceptor agonists (9-45 micrograms kg-1 min-1) were infused into the coronary perfusion line while coronary arterial pressure (CAP) was measured through a distal side arm of the cannula to detect changes in coronary vascular resistance. Infusion of the alpha-adrenoceptor agonists was terminated when systemic arterial pressure increased. Sonomicrometers were used to measure anterior left ventricular wall thickening for the assessment of regional contractile function. During methoxamine infusion, no increase in vascular resistance was observed during alpha-chloralose, enflurane or isoflurane anaesthesia, whereas the infusion of azepexole increased CAP from 103 +/- 31 mmHg to 120 +/- 35 mmHg (alpha-chloralose), from 101 +/- 16 mmHg to 122 +/- 11 mmHg (enflurane) and from 84 +/- 20 mmHg to 94 +/- 19 mmHg (isoflurane), respectively.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
R Schulz; R J Oudiz; B D Guth; G Heusch |
Related Documents
:
|
10440165 - Modulation of left ventricular diastolic distensibility by collateral flow recruitment ... 1742865 - Coronary microvascular resistance in hypertensive cats. 6890825 - Cardiac action of kb-944, a new calcium antagonist. 2957905 - Recovery of systolic and diastolic left ventricular function after a 60-second coronary... 3778685 - Prevention of ammonia-induced brain edema in dogs infused with a branched-chain amino a... 18424685 - Acoustic pressure and particle motion thresholds in six sciaenid fishes. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 342 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1990 Oct |
Date Detail:
|
Created Date: 1991-01-22 Completed Date: 1991-01-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 422-8 Citation Subset: IM |
Affiliation:
|
Abteilung für Pathophysiologie, Universität Essen, Federal Republic of Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic alpha-Agonists
/
pharmacology Adrenergic alpha-Antagonists / pharmacology Anesthesia Animals Blood Pressure / drug effects Coronary Vessels / drug effects* Heart / anatomy & histology, drug effects Muscle, Smooth, Vascular / drug effects* Receptors, Adrenergic, alpha / drug effects, physiology* Swine Vascular Resistance / drug effects Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not med...
Next Document: A kinetic study of the rate of formation of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and hom...