Document Detail

Minimal adverse influence of maternal hepatitis B carrier status on perinatal outcomes and child's growth.
MedLine Citation:
PMID:  25354287     Owner:  NLM     Status:  Publisher    
Abstract Objective: To clarify whether maternal HBsAg positivity may add risk for adverse neonatal outcomes and even affect child's growth. Methods: The perinatal data and neonatal outcomes in 380 HBsAg-positive and 428 HBsAg-negative women delivered during 2002-2004 were investigated. Furthermore, 271 (71.3%) children of HBsAg-positive and 297 (69.4%) of HBsAg-negative mothers were followed at ages of 5-7 years. Child's growth including weight, height, and health conditions were evaluated. Results: The prevalence of preterm birth was relatively higher in HBsAg-positive group (2.9% vs. 1.4%), but it failed to reach statistical significance (p = 0.140). There was no difference in other neonatal outcomes including stillbirth (0.5% vs. 0.2%), neonatal death (0.5% vs. 0.5%) and congenital malformation (0.8% vs. 1.4%). Logistic regression analyses demonstrated maternal HBsAg positivity had no adverse influence on neonatal outcomes. Abnormal health conditions, other than adverse neonatal outcomes, was identified in one child (0.3%) of HBsAg-positive mother and four children (0.9%) of HBsAg-negative mothers at follow-up (p = 0.444). No maternal death occurred in HBsAg-positive or -negative mothers. Conclusions: Maternal HBsAg carrier status does not add risk for adverse neonatal outcomes or child's growth; therefore, heightening surveillance for adverse neonatal complications in HBV-infected pregnant women may be unnecessary.
Jie Chen; Shu Zhang; Yi-Hua Zhou; Biyun Xu; Yali Hu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-29
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-29     Completed Date:  -     Revised Date:  2014-10-30    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-21     Citation Subset:  -    
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