Document Detail


Minimal Inspiratory Flow from Dry Powder Inhalers According to a Biphasic Model of Pressure vs. Flow Relationship.
MedLine Citation:
PMID:  21547884     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Inhalation therapy using the dry powder inhaler (DPI) is now the first choice for obstructive pulmonary diseases. We previously measured relationships between inspiratory pressure (PI) and flow rate of almost all of the DPIs available in Japan, and described an importance of inspiratory efforts. In the present study, we further analyzed the data obtained in the previous study. Although there were linear relationships between PI and flow2, the slope became steeper when PI was less than a certain value (critical PI, existed between 15-20 cmH2O). When PI was less than critical PI, linear rather than parabolic regression between PI and flow yielded better fits (r > 0.90, p < 0.001). Inspiratory flows at the critical PI were 53.9 (Diskus), 65.8 (Diskhaler), 45.9 (Turbuhaler for Pulmincort), 48.6 (Turbuhaler for Symbicort) and 38.0 l/min (Twisthaler). These findings suggested that flow through the DPI becomes laminar rather than turbulent flow in the range below critical PIs. We suggest that patients should inhale from the DPIs with inspiratory pressure higher than critical PI.
Authors:
Kazuo Kanabuchi; Tetsuri Kondo; Toshimori Tanigaki; Sakurako Tajiri; Naoki Hayama; Yoko Takahari; Kayoko Iwao
Related Documents :
9428944 - Reduced gastric emptying and mesenteric blood flow in iddm with cardiac autonomic neuro...
12075384 - Assessment of gut mucosal perfusion and colonic tissue blood flow during abdominal aort...
8321914 - Differences in vascular response to thromboxane between intestinal mucosa and muscularis.
644464 - Effects of intra-arterial infusion of prostaglandin e1 on gastric secretion and blood f...
10969694 - Venovenous perfusion-induced systemic hyperthermia: hemodynamics, blood flow, and therm...
15562074 - Increased carboxyhemoglobin in a patient with a large retroperitoneal hematoma.
Publication Detail:
Type:  Journal Article     Date:  2011-04-20
Journal Detail:
Title:  The Tokai journal of experimental and clinical medicine     Volume:  36     ISSN:  2185-2243     ISO Abbreviation:  Tokai J. Exp. Clin. Med.     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704186     Medline TA:  Tokai J Exp Clin Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cubital tunnel syndrome - a review and management guidelines.
Next Document:  Intramucosal carbon dioxide partial pressure measurement rescued the reconstructed gastric tube.