Document Detail

Minimal Inspiratory Flow from Dry Powder Inhalers According to a Biphasic Model of Pressure vs. Flow Relationship.
MedLine Citation:
PMID:  21547884     Owner:  NLM     Status:  In-Data-Review    
Inhalation therapy using the dry powder inhaler (DPI) is now the first choice for obstructive pulmonary diseases. We previously measured relationships between inspiratory pressure (PI) and flow rate of almost all of the DPIs available in Japan, and described an importance of inspiratory efforts. In the present study, we further analyzed the data obtained in the previous study. Although there were linear relationships between PI and flow2, the slope became steeper when PI was less than a certain value (critical PI, existed between 15-20 cmH2O). When PI was less than critical PI, linear rather than parabolic regression between PI and flow yielded better fits (r > 0.90, p < 0.001). Inspiratory flows at the critical PI were 53.9 (Diskus), 65.8 (Diskhaler), 45.9 (Turbuhaler for Pulmincort), 48.6 (Turbuhaler for Symbicort) and 38.0 l/min (Twisthaler). These findings suggested that flow through the DPI becomes laminar rather than turbulent flow in the range below critical PIs. We suggest that patients should inhale from the DPIs with inspiratory pressure higher than critical PI.
Kazuo Kanabuchi; Tetsuri Kondo; Toshimori Tanigaki; Sakurako Tajiri; Naoki Hayama; Yoko Takahari; Kayoko Iwao
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Publication Detail:
Type:  Journal Article     Date:  2011-04-20
Journal Detail:
Title:  The Tokai journal of experimental and clinical medicine     Volume:  36     ISSN:  2185-2243     ISO Abbreviation:  Tokai J. Exp. Clin. Med.     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704186     Medline TA:  Tokai J Exp Clin Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
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