| Miniglucagon production from glucagon: an extracellular processing of a hormone used as a prohormone. | |
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MedLine Citation:
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PMID: 7819338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucagon is secondarily processed into its C-terminal (19-29) fragment, referred to as 'miniglucagon', which modulates the glucagon action. This extracellular processing, occurring at the level of of the glucagon target cells, is due to the presence at the cell surface of a new 100-kDa processing enzyme with characteristics of both thiol- and metalloprotease. |
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Authors:
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P Blache; A Kervran; D Le-Nguyen; D Bataille |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biochimie Volume: 76 ISSN: 0300-9084 ISO Abbreviation: Biochimie Publication Date: 1994 |
Date Detail:
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Created Date: 1995-02-16 Completed Date: 1995-02-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1264604 Medline TA: Biochimie Country: FRANCE |
Other Details:
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Languages: eng Pagination: 295-9 Citation Subset: IM |
Affiliation:
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INSERM U 376, CCIPE, Montpellier, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cysteine Endopeptidases / metabolism* Female Glucagon / metabolism* Liver / metabolism Male Metalloendopeptidases / metabolism* Models, Biological Organ Specificity Peptide Fragments / metabolism* Protein Processing, Post-Translational* Rats |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 64790-15-4/glucagon (19-29); 9007-92-5/Glucagon; EC 3.4.22.-/Cysteine Endopeptidases; EC 3.4.24.-/Metalloendopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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