| A Miniaturized Extracorporeal Membrane Oxygenator with Integrated Rotary Blood Pump: Preclinical In Vivo Testing. | |
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MedLine Citation:
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PMID: 21317635 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Extracorporeal membrane oxygenation can achieve sufficient gas exchange in severe acute respiratory distress syndrome. A highly integrated extracorporeal membrane oxygenator (HEXMO) was developed to reduce filling volume and simplify management. Six female pigs were connected to venovenous HEXMO with a total priming volume of 125 ml for 4 hours during hypoxemia induced by a hypoxic inspired gas mixture. Animals were anticoagulated with intravenous heparin. Gas exchange, hemodynamics, hemolysis, and coagulation activation were examined. One device failed at the magnetic motor coupling of the integrated diagonal pump. In the remaining five experiments, the oxygenation increased significantly (arterial oxygen saturation [SaO2] from 79 ± 5% before HEXMO to 92% ± 11% after 4 hours) facilitated by a mean oxygen transfer of 66 ± 29 ml/dl through the oxygenator. The CO2 elimination by the HEXMO reduced arterial PaCO2 only marginal. Extracorporeal blood flow was maintained at 32% ± 6% of cardiac output. Hemodynamic instability or hemolysis was not observed. The plasmatic coagulation was only mildly activated without significant platelet consumption. The HEXMO prototype provided sufficient gas exchange to prevent hypoxemia. This proof of concept study supports further development and design modifications to increase performance and to reduce coagulation activation for potential long-term application. |
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Authors:
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Ruedger Kopp; Ralf Bensberg; Jutta Arens; Ulrich Steinseifer; Thomas Schmitz-Rode; Rolf Rossaint; Dietrich Henzler |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-10 |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: - ISSN: 1538-943X ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Department of Intensive Care, University Hospital Aachen; †Department of Anesthesiology, University Hospital Aachen; ‡Department of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany; and §Departments of Anesthesia and Critical Care, Dalhousie University, Halifax, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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