| Miniaturization of powder dissolution measurement and estimation of particle size. | |
| | |
MedLine Citation:
|
PMID: 19937817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The objective was to investigate the applicability and limitations of an approach for estimating particle size from powder dissolution measurement using as little as 50 microg of sample in 1 ml of buffer solutions. The powder dissolution profiles of five sparingly-soluble drugs (hydrochlorothiazide, phenazopyridine hydrochloride, 2-naphthoic acid, indomethacin, and dipyridamole) were evaluated with a novel biexponential spherical particle equation and also the Wang-Flanagan spherical particle non-sink equation. The results were compared to particle sizing based on measured specific surface area by the Brunauer-Emmett-Teller (BET) method, and also based on Coulter counting. With the exception of hydrochlorothiazide, the model compounds indicated some agglomeration in the dissolution media. The dry-state specific surface area was larger than expected from either the Coulter method or the powder-dissolution data, especially for phenazopyridine hydrochloride. The particle radii estimated by the powder dissolution method ranged from 10 to 68 microm, with equilibrium solubilities spanning from 5 microg/ml (dipyridamole) to 911 microg/ml (hydrochlorothiazide). Powder dissolution data collected with the miniaturized apparatus can be used to determine particle size, with estimated values agreeing reasonably with those measured by the Coulter counter method. |
| | |
Authors:
|
Alex Avdeef; Konstantin Tsinman; Oksana Tsinman; Na Sun; Dmytro Voloboy |
Related Documents
:
|
10769787 - Possible mechanism for drug retardation from glyceryl monostearate matrix system. 23452517 - Synthesis and self-assembly of thermo/ph-responsive double hydrophilic brush-coil copol... 23076737 - One-step preparation and ph-tunable self-aggregation of amphoteric aliphatic polycarbon... 23151257 - Adsorption-desorption study of bsa conjugated silver nanoparticles (ag/bsa nps) on coll... 22985847 - Microwave pretreatment of defatted rice bran for enhanced recovery of total phenolic co... 7387177 - Epidermal thinning: evaluation of commercial corticosteroids. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Chemistry & biodiversity Volume: 6 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-12-01 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 1796-811 Citation Subset: IM |
Affiliation:
|
pION Inc., 5 Constitution Way, Woburn, MA 01801, USA. aavdeef@pion-inc.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Chemistry, Pharmaceutical / methods* Hydrogen-Ion Concentration Kinetics Microspheres Miniaturization Models, Chemical Particle Size Pharmaceutical Preparations / chemistry* Powders* Solubility Surface Properties Technology, Pharmaceutical Ultraviolet Rays Viscosity |
| Chemical | |
Reg. No./Substance:
|
0/Pharmaceutical Preparations; 0/Powders |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Kinetic and Thermodynamic Solubility Values of Some Bioactive Compounds.
Next Document: In silico pK(a) Prediction and ADME Profiling.