Document Detail


Miniature magnetic resonance system for point-of-care diagnostics.
MedLine Citation:
PMID:  21547317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a next generation, miniaturized platform to diagnose disease at the point-of-care using diagnostic magnetic resonance (DMR-3). Utilizing a rapidly growing library of functionalized magnetic nanoparticles, DMR has previously been demonstrated as a versatile tool to quantitatively and rapidly detect disease biomarkers in unprocessed biological samples. A major hurdle for bringing DMR to the point-of-care has been its sensitivity to temperature variation. As an alternative to costly and bulky mechanisms to control temperature, we have implemented an automated feedback system to track and compensate for the temperature drift, which enables reliable and robust DMR measurements in realistic clinical environments (4-50 °C). Furthermore, the new system interfaces with a mobile device to facilitate system control and data sharing over wireless networks. With such features, the DMR-3 platform can function as a self-contained laboratory even in resource-limited, remote settings. The clinical potential of the new system is demonstrated by detecting trace amounts of proteins and as few as 10 bacteria (Staphylococcus aureus) in a short time frame (<30 min).
Authors:
David Issadore; Changwook Min; Monty Liong; Jaehoon Chung; Ralph Weissleder; Hakho Lee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-05-05
Journal Detail:
Title:  Lab on a chip     Volume:  11     ISSN:  1473-0189     ISO Abbreviation:  Lab Chip     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-14     Completed Date:  2011-09-30     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  2282-7     Citation Subset:  IM    
Copyright Information:
This journal is © The Royal Society of Chemistry 2011
Affiliation:
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Benchmarking
Magnetic Resonance Imaging / instrumentation*
Miniaturization / instrumentation*
Point-of-Care Systems*
Staphylococcus aureus / isolation & purification
Temperature
Grant Support
ID/Acronym/Agency:
2R01-EB004626/EB/NIBIB NIH HHS; HHSN268201000044C//PHS HHS; HHSN268201000044C//PHS HHS; R01 EB004626-05A1/EB/NIBIB NIH HHS; T32 CA079443-09/CA/NCI NIH HHS; T32-CA79443/CA/NCI NIH HHS; U54 CA119349-01/CA/NCI NIH HHS; U54-CA119349/CA/NCI NIH HHS
Comments/Corrections

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