| Mini review: immune response to myelin-derived sulfatide and CNS-demyelination. | |
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MedLine Citation:
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PMID: 17006761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here we briefly review our understanding of the immune response to myelin-derived glycolipids during an inflammatory autoimmune response in the central nervous system (CNS). We focus primarily on the recognition of the self-glycolipid sulfatide by a distinct population of non-invariant NK T cells. The results of studies we have obtained so far in investigating the presentation of sulfatide by CNS-resident cells including microglia and their interactions with T cells indicate that this pathway might be successfully targeted for the treatment of autoimmune demyelination in multiple sclerosis. |
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Authors:
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Ramesh C Halder; A Jahng; I Maricic; Vipin Kumar |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2006-09-28 |
Journal Detail:
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Title: Neurochemical research Volume: 32 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-08 Completed Date: 2007-03-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
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Laboratory of Autoimmunity, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD1 / physiology Demyelinating Autoimmune Diseases, CNS / immunology* Encephalomyelitis, Autoimmune, Experimental / immunology Galactosylceramides / immunology Glycolipids / immunology Humans Killer Cells, Natural / immunology Mice Multiple Sclerosis / immunology Sulfoglycosphingolipids / immunology* T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD1; 0/Galactosylceramides; 0/Glycolipids; 0/Sulfoglycosphingolipids; 0/alpha-galactosylceramide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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