Document Detail

Mini- and microsatellite expansions: the recombination connection.
MedLine Citation:
PMID:  11265750     Owner:  NLM     Status:  MEDLINE    
It is widely accepted that the large trinucleotide repeat expansions observed in many neurological diseases occur during replication. However, genetic recombination has emerged as a major source of instability for tandem repeats, including minisatellites, and recent studies raise the possibility that it may also be responsible for trinucleotide repeat expansions. We will review data connecting tandem repeat rearrangements and recombination in humans and in eukaryotic model organisms, and discuss the possible role of recombination in trinucleotide repeat expansions in human neurological disorders.
G F Richard; F Pâques
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  EMBO reports     Volume:  1     ISSN:  1469-221X     ISO Abbreviation:  EMBO Rep.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-03-26     Completed Date:  2001-06-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
Unité de Génétique Moléculaire des Levures, URA 2171 CNRS, Paris, France.
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MeSH Terms
DNA / genetics*
DNA Repair
Gene Conversion
Meiosis / genetics,  physiology
Minisatellite Repeats
Models, Genetic
Recombination, Genetic / genetics*
Tandem Repeat Sequences / genetics*
Trinucleotide Repeat Expansion*
Reg. No./Substance:

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