| Mini-mental state examination is sensitive to brain atrophy in Alzheimer's disease. | |
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MedLine Citation:
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PMID: 19786777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Screening instruments such as the Mini-Mental State Examination (MMSE) are useful for the early identification of Alzheimer's disease (AD). We tested whether macrostructural differences in brain volume are related to the MMSE. METHODS: The MMSE was related to cortical thickness and the volume of 19 brain structures in 96 patients with mild to moderate AD. In addition, the patients were compared to 93 healthy elderly controls. RESULTS: The MMSE was related to the volume of the total brain, cerebral cortex, accumbens, cerebral white matter, inferior lateral ventricles and hippocampus. Positive correlations with cortical thickness were found for 41% of the brain surface, and 58% of this area was significantly thinner in AD. CONCLUSION: The MMSE is sensitive to macrostructural brain atrophy in AD, but also to morphometric variation not specifically related to AD. |
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Authors:
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A M Fjell; I K Amlien; L T Westlye; K B Walhovd |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-25 |
Journal Detail:
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Title: Dementia and geriatric cognitive disorders Volume: 28 ISSN: 1421-9824 ISO Abbreviation: Dement Geriatr Cogn Disord Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-23 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705200 Medline TA: Dement Geriatr Cogn Disord Country: Switzerland |
Other Details:
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Languages: eng Pagination: 252-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway. andersmf@psykologi.uio.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / diagnosis, pathology*, psychology* Atrophy Brain / pathology* Female Humans Magnetic Resonance Imaging Male Memory / physiology Middle Aged Nerve Net / pathology Neuropsychological Tests* |
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