| Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats. | |
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MedLine Citation:
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PMID: 20196138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the hippocampus, glucocorticoids bind to two types of receptors: the mineralocorticoid receptor, which binds corticosterone with high affinity and is tonically occupied; and the glucocorticoid receptor, which is occupied during stress and at certain phases in the circadian cycle. Diabetes mellitus increases levels of glucocorticoids in both humans and animal models. To explore the contributions of hippocampal corticosteroid receptors to the diabetes-induced suppression of neuroplasticity, we manipulated these receptors in hippocampal slices from streptozocin-diabetic rats, a model of Type 1 diabetes mellitus. STZ-diabetes reduced long-term potentiation (LTP) at medial perforant path synapses in the dentate gyrus, and induced a bias in favor of long-term depression following intermediate stimulation frequencies. Bath application of the mineralocorticoid receptor agonist aldosterone restored LTP in slices from diabetic animals. These results suggest additional mechanisms for diabetes-induced functional alterations and support a restorative role for dentate gyrus mineralocorticoid receptors. |
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Authors:
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Alexis M Stranahan; Thiruma V Arumugam; Kim Lee; Mark P Mattson |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Synapse (New York, N.Y.) Volume: 64 ISSN: 1098-2396 ISO Abbreviation: Synapse Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-09-08 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8806914 Medline TA: Synapse Country: United States |
Other Details:
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Languages: eng Pagination: 528-32 Citation Subset: IM |
Affiliation:
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Psychology Department, Princeton University, Princeton, New Jersey, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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pharmacology Animals Central Nervous System Agents / pharmacology Dentate Gyrus / drug effects, physiopathology* Diabetes Mellitus, Experimental / physiopathology* Diabetes Mellitus, Type 1 Disease Models, Animal Excitatory Postsynaptic Potentials / drug effects Long-Term Potentiation / drug effects, physiology* Male Neurons / drug effects, physiology Perforant Pathway / drug effects, physiopathology* Rats Rats, Sprague-Dawley Receptors, Mineralocorticoid / agonists, metabolism* Synapses / drug effects, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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F31 AG024690-03/AG/NIA NIH HHS; F31 AG024690-03/AG/NIA NIH HHS; F31 AG024690-04/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Agents; 0/Receptors, Mineralocorticoid; 52-39-1/Aldosterone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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